ID   MDTA_YERPN              Reviewed;         444 AA.
AC   Q1CK59; C4GRP5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=YPN_1291;
GN   ORFNames=YP516_1421;
OS   Yersinia pestis bv. Antiqua (strain Nepal516).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=377628;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nepal516;
RX   PubMed=16740952; DOI=10.1128/jb.00124-06;
RA   Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M.,
RA   Worsham P., Chu M.C., Andersen G.L.;
RT   "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516:
RT   evidence of gene reduction in an emerging pathogen.";
RL   J. Bacteriol. 188:4453-4463(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nepal516;
RA   Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L.,
RA   Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R.,
RA   Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.;
RT   "Yersinia pestis Nepal516A whole genome shotgun sequencing project.";
RL   Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
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DR   EMBL; CP000305; ABG17621.1; -; Genomic_DNA.
DR   EMBL; ACNQ01000008; EEO77736.1; -; Genomic_DNA.
DR   RefSeq; WP_002214676.1; NZ_ACNQ01000008.1.
DR   AlphaFoldDB; Q1CK59; -.
DR   SMR; Q1CK59; -.
DR   EnsemblBacteria; ABG17621; ABG17621; YPN_1291.
DR   GeneID; 57975805; -.
DR   KEGG; ypn:YPN_1291; -.
DR   HOGENOM; CLU_018816_2_0_6; -.
DR   OMA; GQLMAIH; -.
DR   Proteomes; UP000008936; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Repeat; Signal; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           21..444
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_5000115236"
FT   REGION          37..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          398..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   444 AA;  47514 MW;  BF70B791FF55BD01 CRC64;
     MKSQSKRTSR LFVFVGVVVA IIIAVLSWRY FGTGSDNNTS GAQQSARGQD TSHGGRRNTP
     LAPVQAATAT EQEVPRYLTG LGTVIAANTV TVTSRVDGEL MALHFTEGQQ VKAGDLLAEI
     DPRPYEVQLT QAQGQLAKDQ ATLDNARRDL ARYQKLSKTG LISQQELDTQ SSLVRQSEGS
     VKADQGAIDS AKLQLTYSRI TAPISGRVGL KQVDVGNYIT SGTATPIVVI TQTHPVDVVF
     TLPESDIPAI IQAQKNAEKT HAIVPVEAWD RTNKQMLAQG YLLSIDNQID TTTGTIKLKA
     RFNNEDDVLF PNQFVNARIK VDLLQNAVVV PTAAVQMGSE GNFVWTLDDA NKVSKHLVTT
     GIQNSQQVVI DAGLNAGQRV VTDGIDRLTE GVQVEVVTPR SANTDANPAS AEKAAAEAEG
     STPHQGRGRP ANAPARSTTA AEKS