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MDTA_YERPS
ID   MDTA_YERPS              Reviewed;         444 AA.
AC   Q668C7;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 2.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=YPTB2813;
OS   Yersinia pseudotuberculosis serotype I (strain IP32953).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=273123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP32953;
RX   PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA   Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA   Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA   Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA   Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA   Derbise A., Hauser L.J., Garcia E.;
RT   "Insights into the evolution of Yersinia pestis through whole-genome
RT   comparison with Yersinia pseudotuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAH22051.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BX936398; CAH22051.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_011192781.1; NZ_CP009712.1.
DR   AlphaFoldDB; Q668C7; -.
DR   SMR; Q668C7; -.
DR   EnsemblBacteria; CAH22051; CAH22051; YPTB2813.
DR   GeneID; 66844764; -.
DR   KEGG; ypo:BZ17_3818; -.
DR   KEGG; yps:YPTB2813; -.
DR   PATRIC; fig|273123.14.peg.4007; -.
DR   OMA; GQLMAIH; -.
DR   Proteomes; UP000001011; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Signal; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           21..444
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_0000018707"
FT   REGION          37..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          399..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   444 AA;  47591 MW;  C3303C0F56C60AE6 CRC64;
     MKSQSKRTSR LFVFVGVVVA IIIAVLSWRY FGTGSDNNTS GAQQSARGQD TSHGGRRNTP
     LAPVQAATAT EQEVPRYLTG LGTVIAANTV TVTSRVDGEL MALHFTEGQQ VKAGDLLAEI
     DPRPYEVQLT QAQGQLAKDQ ATLDNARRDL ARYQKLSKTG LISQQELDTQ SSLVRQSEGS
     VKADQGAIDS AKLQLTYSRI TAPISGRVGL KQVDVGNYIT SGTATPIVVI TQTHPVDVVF
     TLPESDIPAI MQAQKNAEKT HAIVPVEAWD RTNKQMLAQG YLLSIDNQID TTTGTIKLKA
     RFNNEDDVLF PNQFVNARIK VDLLQNAVVV PTAAVQMGSE GNFVWTLDDA NRVSKHLVTT
     GIQDSQQVVI DAGLNAGQRV VTDGIDRLTE GVQVEVVTPR SANTDTNPAS AEKAAAEAEG
     STPHQGRGRP ANAPARSTTA AEKS
 
 
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