ID   MDTA_YERPY              Reviewed;         444 AA.
AC   B1JSD5;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Multidrug resistance protein MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   AltName: Full=Multidrug transporter MdtA {ECO:0000255|HAMAP-Rule:MF_01422};
DE   Flags: Precursor;
GN   Name=mdtA {ECO:0000255|HAMAP-Rule:MF_01422}; OrderedLocusNames=YPK_1332;
OS   Yersinia pseudotuberculosis serotype O:3 (strain YPIII).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=502800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YPIII;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C.,
RA   Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Challacombe J.F., Green L., Lindler L.E., Nikolich M.P., Richardson P.;
RT   "Complete sequence of Yersinia pseudotuberculosis YPIII.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. {ECO:0000255|HAMAP-Rule:MF_01422}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01422}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01422}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01422}.
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DR   EMBL; CP000950; ACA67626.1; -; Genomic_DNA.
DR   RefSeq; WP_012303862.1; NZ_CP009792.1.
DR   AlphaFoldDB; B1JSD5; -.
DR   SMR; B1JSD5; -.
DR   EnsemblBacteria; ACA67626; ACA67626; YPK_1332.
DR   KEGG; ypy:YPK_1332; -.
DR   PATRIC; fig|502800.11.peg.1967; -.
DR   OMA; GQLMAIH; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01422; MdtA; 1.
DR   InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR   InterPro; IPR022824; Multidrug-R_MdtA.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF13533; Biotin_lipoyl_2; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Repeat; Signal; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01422"
FT   CHAIN           21..444
FT                   /note="Multidrug resistance protein MdtA"
FT                   /id="PRO_1000145646"
FT   REGION          37..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          398..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   444 AA;  47562 MW;  1A7665522E427277 CRC64;
     MKSQSKRTSR LFVFVGVVVA IIIAVLSWRY FGTGSDNNTS GAQQSARGQD TSHGGRRNTP
     LAPVQAATAT EQEVPRYLTG LGTVIAANTV TVTSRVDGEL MALHFTEGQQ VKAGDLLAEI
     DPRPYEVQLT QAQGQLAKDQ ATLDNARRDL ARYQKLSKTG LISQQELDTQ SSLVRQSEGS
     VKADQGAIDS AKLQLTYSRI TAPISGRVGL KQVDVGNYIT SGTATPIVVI TQTHPVDVVF
     TLPESDIPAI MQAQKNAEKT HAIVPVEAWD RTNKQMLAQG YLLSIDNQID TTTGTIKLKA
     RFNNEDDVLF PNQFVNARIK VDLLQNAVVV PTAAVQMGSE GNFVWTLDDA NKVSKHLVTT
     GIQNSQQVVI DAGLNAGQRV VTDGIDRLTE GVQVEVVTPR SANTDTNPAS AEKAAAEAEG
     STPHQGRGRP ANAPARSTTA AEKS