ID   MDTB_CROS8              Reviewed;        1040 AA.
AC   A7MHJ1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Multidrug resistance protein MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
DE   AltName: Full=Multidrug transporter MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
GN   Name=mdtB {ECO:0000255|HAMAP-Rule:MF_01423}; OrderedLocusNames=ESA_01143;
OS   Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Cronobacter.
OX   NCBI_TaxID=290339;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-894;
RX   PubMed=20221447; DOI=10.1371/journal.pone.0009556;
RA   Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L.,
RA   Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A.,
RA   Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K.,
RA   McClelland M., Forsythe S.J.;
RT   "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic
RT   hybridization analysis with other Cronobacter species.";
RL   PLoS ONE 5:E9556-E9556(2010).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtB forms a heteromultimer with MdtC. {ECO:0000255|HAMAP-
CC       Rule:MF_01423}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01423}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01423}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtB subfamily. {ECO:0000255|HAMAP-Rule:MF_01423}.
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DR   EMBL; CP000783; ABU76410.1; -; Genomic_DNA.
DR   RefSeq; WP_012124312.1; NC_009778.1.
DR   AlphaFoldDB; A7MHJ1; -.
DR   SMR; A7MHJ1; -.
DR   EnsemblBacteria; ABU76410; ABU76410; ESA_01143.
DR   KEGG; esa:ESA_01143; -.
DR   PATRIC; fig|290339.8.peg.1013; -.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; LEPFIIM; -.
DR   OrthoDB; 145346at2; -.
DR   Proteomes; UP000000260; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01423; MdtB; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR022831; Multidrug-R_MdtB.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1040
FT                   /note="Multidrug resistance protein MdtB"
FT                   /id="PRO_1000024303"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        440..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        472..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        537..557
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        863..883
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        888..908
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        911..931
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        968..988
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        998..1018
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
SQ   SEQUENCE   1040 AA;  111499 MW;  C04EC6947B14AD18 CRC64;
     MQVLPPSATG GPSRLFILRP VATTLLMVAI LLAGIIGYRF LPVSALPEVD YPTIQVVTLY
     PGASPDVVTS AITAPLERQF GQMSGLKQMA SQSAGGASVV TLQFQLTLPL DVAEQEVQAA
     INAATNLLPD DLPNPPVYSK VNPADPPIMT LAVTSSALPM TQVEDMVETR VAQRISQVTG
     VGLVTLSGGQ RPAVRVKLNA QALASLGIDS ETVRTAITSA NVNSAKGSFD GPERAVTLSA
     NDQMKSADEY RNLIIAYKNG APVRLGDVAT VEQGAENAWL GAWANKQPAI VMNVQRQPGA
     NIITTAETIQ KLLPQLTESL PKSVQVKVLT DRTTNISASV NDTQFELMLA IALVVMIIYL
     FLRNIPATII PAVAVPLSLV GTFAVMVFLD FSINNLTLMA LTIATGFVVD DAIVVIENIS
     RYIEKGEKPL AAALKGAGEI GFTIISLTFS LIAVLIPLLF MGDIVGRLFR EFAVTLAVAI
     LISAVVSLTL TPMMCARMLS HESLRKQNRF SRASERVINR VIARYGQLLK RVLNHPWLTL
     GVALGTLALT VLLWIFIPKG FFPVQDNGII QGTLQAPQSV SFASMAERQR AVADVILKDP
     AVESLTSFVG VDGTNPSLNS ARLQINLKPL DDRDDRVQTV IARLQEAASR VPGATLYLQP
     IQDLTIDTQV SRTQYQFTLQ ANSLEALSTW VPKLIARLQT LPQLADVSSD WQDNGLVAYV
     NVDRASASRL GISMSDVDNA LYNAFGQRLI STIYTQANQY RVVLEHNTTA TPGLAALDGI
     RLASSDGGMV PLSAIAKVEQ RFGPLTINHL DQFPSTTISF NVPDGYSLGD AVDAITQAEA
     DLAFPAEITT QFQGSTLAFQ AALGSTLWLI LASVVAMYIV LGVLYESFIH PITILSTLPT
     AGVGALLALL IAGAELDVIA IIGIILLIGI VKKNAIMMID FALAAEREQG MTPREAIYQA
     CLLRFRPILM TTLAALLGAL PLMLSTGVGA ELRRPLGIGM VGGLLVSQVL TLFTTPVIYL
     LFDRLGHAVR RRLPAREEEA