ID   MDTB_EDWTE              Reviewed;        1042 AA.
AC   D0ZEW1;
DT   16-NOV-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Multidrug resistance protein MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
DE   AltName: Full=Multidrug transporter MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
GN   Name=mdtB {ECO:0000255|HAMAP-Rule:MF_01423}; OrderedLocusNames=ETAE_1070;
OS   Edwardsiella tarda (strain EIB202).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=498217;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EIB202;
RX   PubMed=19865481; DOI=10.1371/journal.pone.0007646;
RA   Wang Q., Yang M., Xiao J., Wu H., Wang X., Lv Y., Xu L., Zheng H., Wang S.,
RA   Zhao G., Liu Q., Zhang Y.;
RT   "Genome sequence of the versatile fish pathogen Edwardsiella tarda provides
RT   insights into its adaptation to broad host ranges and intracellular
RT   niches.";
RL   PLoS ONE 4:E7646-E7646(2009).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtB forms a heteromultimer with MdtC. {ECO:0000255|HAMAP-
CC       Rule:MF_01423}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01423}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01423}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtB subfamily. {ECO:0000255|HAMAP-Rule:MF_01423}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001135; ACY83915.1; -; Genomic_DNA.
DR   RefSeq; WP_012847934.1; NC_013508.1.
DR   AlphaFoldDB; D0ZEW1; -.
DR   SMR; D0ZEW1; -.
DR   EnsemblBacteria; ACY83915; ACY83915; ETAE_1070.
DR   KEGG; etr:ETAE_1070; -.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; FIIPCFY; -.
DR   OrthoDB; 145346at2; -.
DR   Proteomes; UP000002634; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01423; MdtB; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR022831; Multidrug-R_MdtB.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1042
FT                   /note="Multidrug resistance protein MdtB"
FT                   /id="PRO_0000414030"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        399..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        443..463
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        475..495
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        541..561
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        872..892
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        893..913
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        914..934
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        971..991
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        1001..1021
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
SQ   SEQUENCE   1042 AA;  111985 MW;  5819381A128CDEC7 CRC64;
     MSQTPSSPVP RGGGPSRLFI LRPVATTLLM IAILLAGLVA YRALPVSALP QVDYPTIQVV
     TLYPGASPDV TASAITAPLE RQFGQMSGLQ QMSSQSSGGA SVITLQFQLS LALDVAEQEV
     QAAINAATNL LPNDLPYPPI YSKVNPADPP ILTLAVVSDA LSLPQVEDLV ETRISQKIAQ
     VGGVGLVTLA GGQRPAVRVR LNGAAAAAYG LSSETIRSAI ANANVNSPKG SLDGPTRAIT
     LNANDQLRSA QEYQNLIVAY RSGAPVYLRD IASVEQGAEN TQLAAWANNH PAIVINVQRQ
     PGANVIATAD AVLAQLPQLR ESLPASVKIS VLNDRTQTIR ASVSDVRHEL LLAVALVVMV
     IYLFLRNLPA TLIPGVAVPL SLIGTFAAMY FLGFSINNLT LMALTIATGF VVDDAIVVIE
     NIERHLENGD PPLRAALKGA GEIGFTIISL TFSLIAVLIP LLFMGDIIGR LFREFAVTLA
     VAILISAVVS LTLTPMMCAR LLSQESLRRQ NRFSLACERQ FQRLIAGYGR ALRLALRHPR
     ITLGVAVATL MLTVLLYLII PKGFFPQQDN SLIQGTVYAP QSISFSAMAE RQRQLSEALL
     RDPDVASVSA FVGVDGVNPA LNSGRLQIVL KPLADRRDRI DRIIPRLQAL AARVGGISLY
     LQPVQDMTID TLPGRARYPF TLQAMSLDEL QTWVPRLQAR LAQSPMLKDV NSDWQDQGLV
     AYVNVNRDSA SRLGIAMQDV DNALYNAFGQ RLISTIYTQS NQYRVVLEQE RAHQDGLTAL
     QRIYLTAADG SAIPLASIAT VEQRHGVLAI NHLDQFPSAT LSFNVPDGYT LEQAIAEIDA
     ARRAIGMPAD MTLHFQGAAL AFQSALDSTL WLILAAIVAM YIVLGILYES FIHPITILST
     LPSAGVGALL ALMISGQALD VIAIIGIILL IGIVKKNAIM MIDFALAAER TQGMAPHDAI
     YQACLLRFRP ILMTTMAALL GALPLMFSQG VGAELRQPLG ICMVGGLIVS QILTLFTTPV
     IYLAFDRLAR NTHRPTRGVP AR