ID   MDTB_ENT38              Reviewed;        1040 AA.
AC   A4WCC1;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Multidrug resistance protein MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
DE   AltName: Full=Multidrug transporter MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
GN   Name=mdtB {ECO:0000255|HAMAP-Rule:MF_01423}; OrderedLocusNames=Ent638_2685;
OS   Enterobacter sp. (strain 638).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter.
OX   NCBI_TaxID=399742;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=638;
RX   PubMed=20485560; DOI=10.1371/journal.pgen.1000943;
RA   Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D.,
RA   Vangronsveld J., Newman L., Monchy S.;
RT   "Genome sequence of the plant growth promoting endophytic bacterium
RT   Enterobacter sp. 638.";
RL   PLoS Genet. 6:E1000943-E1000943(2010).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtB forms a heteromultimer with MdtC. {ECO:0000255|HAMAP-
CC       Rule:MF_01423}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01423}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01423}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtB subfamily. {ECO:0000255|HAMAP-Rule:MF_01423}.
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DR   EMBL; CP000653; ABP61351.1; -; Genomic_DNA.
DR   RefSeq; WP_015959684.1; NC_009436.1.
DR   AlphaFoldDB; A4WCC1; -.
DR   SMR; A4WCC1; -.
DR   STRING; 399742.Ent638_2685; -.
DR   EnsemblBacteria; ABP61351; ABP61351; Ent638_2685.
DR   KEGG; ent:Ent638_2685; -.
DR   eggNOG; COG0841; Bacteria.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; FIIPCFY; -.
DR   OrthoDB; 145346at2; -.
DR   Proteomes; UP000000230; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01423; MdtB; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR022831; Multidrug-R_MdtB.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1040
FT                   /note="Multidrug resistance protein MdtB"
FT                   /id="PRO_1000068504"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        342..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        440..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        472..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        537..557
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        869..889
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        890..910
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        911..931
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        968..988
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        998..1018
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
SQ   SEQUENCE   1040 AA;  111936 MW;  9A9C6F09E7E302FF CRC64;
     MQVLPPSSTG GPSRLFIMRP VATTLLMVAI LIAGIIGYRF LPVSALPEVD YPTIQVITLY
     PGASPDVVTS AITAPLERQF GQMSGLKQMS SQSSGGASVV TLQFQLTLPL DVAEQEVQAA
     INAATNLLPS DLPNPPVYSK VNPADPPIMT LAVTSSAMPM TQVEDMVETR VAQKISQVSG
     VGLVTLSGGQ RPAVRVKLNA QAIAALGLTS ETIRTAIVSA NVNSAKGSLD GPTRAVTLSA
     NDQMQSADEY RQLIVAYQNG APIRLGDVAT VEQGAENRWL GAWANKEQAI VMNVQRQPGA
     NIIDTADSIR AMLPQLIESL PKSVNVKVLS DRTTNIRASV SDTQFELMLA MALVVMIIYV
     FLRNVPATII PAVAVPLSLV GTFAVMVFLD FSINNLTLMA LTIATGFVVD DAIVVIENIS
     RYIEKGEKPL AAALKGAGEI GFTIISLTFS LIAVLIPLLF MGDIVGRLFR EFAVTLAVAI
     LISAVVSLTL TPMMCARMLS AESLRKQNRF SRASERMFER IIAAYGRMLE KVLNHPWATL
     SVALGTLALS VMLWIVIPKG FFPIQDNGII QGTLQAPQSV SFASMAQRQQ AVSDVIMKDP
     AVESLTSFVG VDGTNPSLNS ARLQINLKPL DDRDDRVNTV IERLQSAVAK VPGVELYLQP
     TQDLTIDTTV SRTQYQFTLQ ATSLEALSTW VPQLVTKLQE LPQLSDVSSD WQDKGLAAYV
     NVNRDTASRL GISMADVDNA LYNAFGQRLI STIYTQANQY RVVLEHNTEQ TPGLTALDTV
     RLTSKNGGIV PLSAIATVEQ RFAPLSINHL DQFPSTTISF NVPDNYSLGE AVESILNAEK
     TLNFPTDIQT QFQGSTLAFQ AALGNTIWLI VAAVVAMYIV LGVLYESFIH PVTILSTLPT
     AGVGALLALM LSGSELDVIA IIGIILLIGI VKKNAIMMID FALAAEREQG MAPRDAIFQA
     CLLRFRPILM TTMAALLGAL PLMLSTGVGA ELRRPLGIGM VGGLLVSQVL TLFTTPVIYL
     LFDTLALKMK ARFPKREEEA