ID   MDTB_MUSP7              Reviewed;        1040 AA.
AC   C6CAI2;
DT   16-NOV-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Multidrug resistance protein MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
DE   AltName: Full=Multidrug transporter MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
GN   Name=mdtB {ECO:0000255|HAMAP-Rule:MF_01423}; OrderedLocusNames=Dd703_2703;
OS   Musicola paradisiaca (strain Ech703) (Dickeya paradisiaca) (Dickeya
OS   dadantii).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Musicola.
OX   NCBI_TaxID=579405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ech703;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Balakrishnan V., Glasner J., Perna N.T.;
RT   "Complete sequence of Dickeya dadantii Ech703.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtB forms a heteromultimer with MdtC. {ECO:0000255|HAMAP-
CC       Rule:MF_01423}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01423}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01423}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtB subfamily. {ECO:0000255|HAMAP-Rule:MF_01423}.
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DR   EMBL; CP001654; ACS86480.1; -; Genomic_DNA.
DR   RefSeq; WP_015854385.1; NC_012880.1.
DR   AlphaFoldDB; C6CAI2; -.
DR   SMR; C6CAI2; -.
DR   STRING; 579405.Dd703_2703; -.
DR   EnsemblBacteria; ACS86480; ACS86480; Dd703_2703.
DR   KEGG; dda:Dd703_2703; -.
DR   eggNOG; COG0841; Bacteria.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; FIIPCFY; -.
DR   Proteomes; UP000002734; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01423; MdtB; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR022831; Multidrug-R_MdtB.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1040
FT                   /note="Multidrug resistance protein MdtB"
FT                   /id="PRO_0000414029"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        342..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        440..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        472..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        537..557
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        865..885
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        888..908
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        911..931
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        968..988
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        1002..1022
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
SQ   SEQUENCE   1040 AA;  112391 MW;  3E0110C9A9ED910F CRC64;
     MQESSPIHGG GPSRLFILRP VATTLLMVAI LLAGLVGYRA LPVSALPEVD YPTIQVVTLY
     PGASPDVMTS SVTAPLEHQF GSMSGLKQMS SQSSAGASVI TLQFQLTLSL DVAEQDVQAA
     INAATNLLPT DLPFPPTYNK VNPADPPIMT LAVTSTAMPM TQVQDMLETR IAQKISQVEG
     VGLVTLAGGQ RPSVRVKLNA GALASFGLSS ESVRTAITAA NVNTPKGSFD GPTRSVTLSA
     NDQIRSVDDY RQLIITWKNN APVRLQDVAT VEQAPENTKL AAWANQNQAI ILNIQRQPGA
     NVIATADHIR NLLPTLQASL PKSVNVTLLA DRTTTIRASV DDVQFELLLA IALVVMVIYL
     FLRNAVATLI PSIAVPLSLV GTFAAMYFLG FSVNNLTLMA LTIATGFVVD DAIVVIENIA
     RYIEKGEKPL DAALKGAGEI GFTIISLTFS LIAVLIPLLF MGDIIGRLFR EFAVTLAVSI
     LISAIVSLTL TPMMCARLLN HEALAHQNRF TRASERFFDW VIAAYGRGLT RVLSHPWITL
     SVAIGTLVLT VLLYIVIPKG FFPIQDNGII QGTVQAAQTI SFNSMVDKQH QVTDAILKDP
     TVESVSSFIG VDGTNPSLNS GRLQINLKPF SERSERVQTI IDRLQQQAAA IPGVQLYLQP
     VQDLTIDTQV SRTQYQFTLQ TMSLDELGVW VPKLTAELQK LPQLQDVSSD WQDGAAVAYV
     KVDRDNASRL GITMSQIDSA LYNAFGQRLI STIYTQSNQY RVVLEQHSPN KTGLDPLHDI
     RLVNSTGGVV PLDSIATIEE RNGTLAVNHI DQFPSSTISF NVAPGYALGD AVKAIETTQQ
     QMQLPSDIIT RFQGSTLAFQ AALTSTIWLV VAAIVAMYIV LGVLYESFIH PVTILSTLPT
     AGVGALLALM ISGSDLNIIA IIGIILLIGI VKKNAIMMID FALAAEREHG MSPYQAIYQA
     CLLRFRPILM TTMAALLSAV PLMFSTGVGA ELRRPLGICM VGGLVMSQVL TLFTTPVIYL
     LFDRLAHRLR RPRPQEGEAQ