MDTB_PECAS
ID MDTB_PECAS Reviewed; 1040 AA.
AC Q6D2B1;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Multidrug resistance protein MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
DE AltName: Full=Multidrug transporter MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
GN Name=mdtB {ECO:0000255|HAMAP-Rule:MF_01423}; OrderedLocusNames=ECA3185;
OS Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS carotovora subsp. atroseptica).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Pectobacteriaceae; Pectobacterium.
OX NCBI_TaxID=218491;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCRI 1043 / ATCC BAA-672;
RX PubMed=15263089; DOI=10.1073/pnas.0402424101;
RA Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J.,
RA Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K.,
RA Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J.,
RA Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Norbertczak H.,
RA Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S.,
RA Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K.;
RT "Genome sequence of the enterobacterial phytopathogen Erwinia carotovora
RT subsp. atroseptica and characterization of virulence factors.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004).
CC -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC MdtC. MdtB forms a heteromultimer with MdtC. {ECO:0000255|HAMAP-
CC Rule:MF_01423}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01423}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01423}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MdtB subfamily. {ECO:0000255|HAMAP-Rule:MF_01423}.
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DR EMBL; BX950851; CAG76083.1; -; Genomic_DNA.
DR RefSeq; WP_011094707.1; NC_004547.2.
DR AlphaFoldDB; Q6D2B1; -.
DR SMR; Q6D2B1; -.
DR STRING; 218491.ECA3185; -.
DR PRIDE; Q6D2B1; -.
DR EnsemblBacteria; CAG76083; CAG76083; ECA3185.
DR GeneID; 57209870; -.
DR KEGG; eca:ECA3185; -.
DR PATRIC; fig|218491.5.peg.3226; -.
DR eggNOG; COG0841; Bacteria.
DR HOGENOM; CLU_002755_1_2_6; -.
DR OMA; FIIPCFY; -.
DR OrthoDB; 145346at2; -.
DR Proteomes; UP000007966; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.2090.10; -; 2.
DR HAMAP; MF_01423; MdtB; 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR022831; Multidrug-R_MdtB.
DR PANTHER; PTHR32063; PTHR32063; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82714; SSF82714; 2.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1040
FT /note="Multidrug resistance protein MdtB"
FT /id="PRO_0000161824"
FT TRANSMEM 15..37
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 343..365
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 369..391
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 398..420
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 440..462
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 474..496
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 535..557
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 867..889
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 909..931
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 968..990
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 1000..1022
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
SQ SEQUENCE 1040 AA; 112563 MW; F997510F1824356B CRC64;
MQDNVPASGG GPSRLFILRP VATTLLMIAI LLAGIIGYRA LPVSALPEVD YPTIQVITLY
PGASPDVVTS AITAPLERQF GQMSGLKQMS TQSAGGASVI TLQFQLELSL DVAEQDVQAA
INAASNLLPN DLPYPPTYSK VNPADPPIMT LAVTSSAMSM TQVQDMVDNR IAQKISQVAG
VGLVSLAGGQ RPAVRVRLNA PALAAYGLTS ETIRTAITAA NVNSAKGSLD GPTRSVTLSA
NDQMKSVDDY RKLIVAWKNG APVRLQDVAT IEQAAENIYL GAWANRQQAI IINVQRQPGA
NVITTTDSIN KMLPALKASL PNSVEVATLT DRTTSIRASV KDVQFELLLA IALVVMVIYL
FLRNAVATLI PSIAVPLSLV GTFAAMYFLG FSINNLTLMA LTIATGFVVD DAIVVIENIA
RYIEKGEKPL NAALKGAGEI GFTIISLTFS LIAVLIPLLF MGDIVGRLFR EFAVTLAVSI
LISAVVSLTL TPMMCARMLS HQSLRKQNRF TRASERFFTR LIDTYGTWLR KVLNHPWLTL
SVALGTLLLT ILLYIWIPKG FFPIQDNGII QGTVQAPQTV SFSNMADRQQ RVASIIMKDP
TVESVSSFIG VDGTNAALNS GRLQINLKPL SERSERIPEI ISRLQQQTAQ IPGIQLYLQP
VQDLTIDTQI SRTQYQFTLQ AMSLDELSVW VPKLMTELKK LPQLEDVSSD WQDGAAVAYV
NVDRDSASRL GITMSQVDSA LYNAFGQRLV STIYTQASQY RVVLEHDTTN NTGLDALNDV
RLISSDGGTI PLSSIATIEE RQGPLAINHI DQFPSTTISF NVASGYALGE AVDAITQAEQ
QMNLPADITT RFQGSTLAFQ SALSSTVWLI VAAIVAMYIV LGVLYESFIH PITILSTLPT
AGVGALLALM MAGKDLDVIA IIGIILLIGI VKKNAIMMID FALAAEREQG MKPYDAIYQA
CLLRFRPILM TTMAALLSAL PLMLSTGVGA ELRQPLGVCM VGGLIMSQIL TLFTTPVIYL
LFDRLATRFR RVPRQEEETE
