ID   MDTB_PHOLL              Reviewed;        1048 AA.
AC   Q7N3E2;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Multidrug resistance protein MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
DE   AltName: Full=Multidrug transporter MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
GN   Name=mdtB {ECO:0000255|HAMAP-Rule:MF_01423}; OrderedLocusNames=plu2775;
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtB forms a heteromultimer with MdtC. {ECO:0000255|HAMAP-
CC       Rule:MF_01423}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01423}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01423}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtB subfamily. {ECO:0000255|HAMAP-Rule:MF_01423}.
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DR   EMBL; BX571868; CAE15149.1; -; Genomic_DNA.
DR   RefSeq; WP_011146995.1; NC_005126.1.
DR   AlphaFoldDB; Q7N3E2; -.
DR   SMR; Q7N3E2; -.
DR   STRING; 243265.plu2775; -.
DR   EnsemblBacteria; CAE15149; CAE15149; plu2775.
DR   GeneID; 24170415; -.
DR   KEGG; plu:plu2775; -.
DR   eggNOG; COG0841; Bacteria.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; FIIPCFY; -.
DR   OrthoDB; 145346at2; -.
DR   BioCyc; PLUM243265:PLU_RS13765-MON; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01423; MdtB; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR022831; Multidrug-R_MdtB.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1048
FT                   /note="Multidrug resistance protein MdtB"
FT                   /id="PRO_0000161825"
FT   TRANSMEM        15..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        345..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        366..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        395..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        437..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        472..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        535..557
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        867..889
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        909..931
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        968..990
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        1000..1022
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
SQ   SEQUENCE   1048 AA;  113653 MW;  BF1B57C65BE29916 CRC64;
     MQAGSPIPGG GPSRLFILRP VATTLFMAAI LLAGIIGYRM LPVSALPEVD YPTIQVVTLY
     PGASPDVMTS AVTAPLERQL GQMSGLKQMA SQSSGGASVI TLQFQLTLPL DVAEQEVQAA
     INAASNLLPN DLPYPPIYSK VNPADPPILM LAVTSDAMPM TQIQDMVETR IAQKISQVNG
     VGLVTLAGGQ RPAVRVKLNA QAVAAQGLDS ETIRTAINNA NVNSAKGSLD GPTRSVTLSA
     NDQMKSVNDY RNLIIAYKNG SPVRLQDVAT IEQGAENTKL GAWSNNTQAI VINVQRQPGA
     NVIETTDNIR QMLPELISSL PKSVDMKILT DRTTTIRASV KDVQFELLLA IALVVMVIYL
     FLRNGIATLI PSIAVPLSLI GTFAVMYFCG FSVNNLTLMA LTIATGFVVD DAIVVIENIS
     RYIEQGEKPM TAALKGAGEI GFTIISLTFS LIAVLIPLLF MGDIVGRLFR EFAITLAVAI
     LISAVVSLTL TPMMCARILK PESQIKHNRF EQASGRFFEQ MIAGYAVWLK RALNHPWITF
     GIALSTLALT ALLYLMIPKG FFPSQDNGLI QGTLEAPQSI SFTAMVNKQQ QVSSLLLQDP
     AVENITTFVG VDGSNPTLNN GRLQITLKPL NQRDDRIVDI IPRLQEKVAA IPGIKLYLQP
     MQDLTIDTQV TRTQYQFTLQ ATSLDELSIW VPKLLAELKQ RAELVDISSD WQDQGLIAYV
     KVDRDIASRL GISMAAIDNA LYNAFGQRLI STIYTQANQY RIILEHDVTS TPGLAAFDNI
     RLNGTDGHVV PLRTIATIEQ KFGPLAINHL AQFPSATFSF NVAEDASLEQ AVNAVRDAAQ
     LINMPKDIST QFQGTTLAFE SALGNTLWLI AAAIIAMYIV LGILYESFIH PVTILSTLPT
     AGVGALLALM MAGHELDVIA IIGIILLIGI VKKNAIMMID FALAAEREQG LSPYEAIYQA
     CLLRFRPILM TTMAALLGAL PLMLSTGVGA ELRRPLGICM VGGLIMSQIL TLFTTPVIYL
     LFDRLAHYRR NRQLSVSNTP SIDHQEPR