ID   MDTB_SALPA              Reviewed;        1040 AA.
AC   Q5PDW7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Multidrug resistance protein MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
DE   AltName: Full=Multidrug transporter MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
GN   Name=mdtB {ECO:0000255|HAMAP-Rule:MF_01423}; OrderedLocusNames=SPA0738;
OS   Salmonella paratyphi A (strain ATCC 9150 / SARB42).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=295319;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9150 / SARB42;
RX   PubMed=15531882; DOI=10.1038/ng1470;
RA   McClelland M., Sanderson K.E., Clifton S.W., Latreille P., Porwollik S.,
RA   Sabo A., Meyer R., Bieri T., Ozersky P., McLellan M., Harkins C.R.,
RA   Wang C., Nguyen C., Berghoff A., Elliott G., Kohlberg S., Strong C., Du F.,
RA   Carter J., Kremizki C., Layman D., Leonard S., Sun H., Fulton L., Nash W.,
RA   Miner T., Minx P., Delehaunty K., Fronick C., Magrini V., Nhan M.,
RA   Warren W., Florea L., Spieth J., Wilson R.K.;
RT   "Comparison of genome degradation in Paratyphi A and Typhi, human-
RT   restricted serovars of Salmonella enterica that cause typhoid.";
RL   Nat. Genet. 36:1268-1274(2004).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtB forms a heteromultimer with MdtC. {ECO:0000255|HAMAP-
CC       Rule:MF_01423}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01423}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01423}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtB subfamily. {ECO:0000255|HAMAP-Rule:MF_01423}.
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DR   EMBL; CP000026; AAV76736.1; -; Genomic_DNA.
DR   RefSeq; WP_001197809.1; NC_006511.1.
DR   AlphaFoldDB; Q5PDW7; -.
DR   SMR; Q5PDW7; -.
DR   EnsemblBacteria; AAV76736; AAV76736; SPA0738.
DR   KEGG; spt:SPA0738; -.
DR   HOGENOM; CLU_002755_1_1_6; -.
DR   OMA; FIIPCFY; -.
DR   Proteomes; UP000008185; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01423; MdtB; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR022831; Multidrug-R_MdtB.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1040
FT                   /note="Multidrug resistance protein MdtB"
FT                   /id="PRO_1000024306"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        440..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        472..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        537..557
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        863..883
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        888..908
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        910..930
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        968..988
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        998..1018
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
SQ   SEQUENCE   1040 AA;  111800 MW;  42605E83216F8BB9 CRC64;
     MQVLPPGSTG GPSRLFILRP VATTLLMAAI LLAGIIGYRF LPVAALPEVD YPTIQVVTLY
     PGASPDVMTS SVTAPLERQF GQMSGLKQMS SQSSGGASVV TLQFQLTLPL DVAEQEVQAA
     INAATNLLPS DLPNPPIYSK VNPADPPIMT LAVTSNAMPM TQVEDMVETR VAQKISQVSG
     VGLVTLAGGQ RPAIRVKLNA QAIAALGLTS ETVRTAITGA NVNSAKGSLD GPERAVTLSA
     NDQMQSADEY RKLIIAYQNG APVRLGDVAT VEQGAENSWL GAWANQAPAI VMNVQRQPGA
     NIIATADSIR QMLPQLTESL PKSVKVTVLS DRTTNIRASV RDTQFELMLA IALVVMIIYL
     FLRNIPATII PGVAVPLSLI GTFAVMVFLD FSINNLTLMA LTIATGFVVD DAIVVIENIS
     RYIEKGEKPL AAALKGAGEI GFTIISLTFS LIAVLIPLLF MGDIVGRLFR EFAVTLAVAI
     LISAVVSLTL TPMMCACMLS QQSLRKQNRF SRACERMFDR VIASYGRGLA KVLNHPWLTL
     SVAFATLLLS VMLWIVIPKG FFPVQDNGII QGTLQAPQSS SYASMAQRQR QVAERILQDP
     AVQSLTTFVG VDGANPTLNS ARLQINLKPL DARDDRVQQV ISRLQTAVAT IPVVALYLQP
     TQDLTIDTQV SRTQYQFTLQ ATTLDALSHW VPKLQNALQS LPQLSEVSSD WQDRGLAAWV
     NVDRDSASRL GISIADVDNA LYNAFGQRLI STIYTQANQY RVVLEHNTAS TPGLAALETI
     RLTSRDGGTV SLSAIARIEQ RFAPLSINHL DQFPVTTFSF NVPEGYSLGD AVQAILDTEK
     TLALPADITT QFQGSTLAFQ AALGSTVWLI VAAVVAMYIV LGVLYESFIH PITILSTLPT
     AGVGALLALI IAGSELDIIA IIGIILLIGI VKKNAIMMID FALAAEREQG MSPRDAIFQA
     CLLRFRPILM TTLAALLGAL PLMLSTGVGA ELRRPLGIAM VGGLLVSQVL TLFTTPVIYL
     LFDRLSLYVK SRFPRHKEEA