MDTB_SALTI
ID MDTB_SALTI Reviewed; 1040 AA.
AC Q8Z5F7; Q7CAY6;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Multidrug resistance protein MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
DE AltName: Full=Multidrug transporter MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
GN Name=mdtB {ECO:0000255|HAMAP-Rule:MF_01423};
GN OrderedLocusNames=STY2340, t0745;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC MdtC. MdtB forms a heteromultimer with MdtC. {ECO:0000255|HAMAP-
CC Rule:MF_01423}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01423}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01423}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MdtB subfamily. {ECO:0000255|HAMAP-Rule:MF_01423}.
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DR EMBL; AL513382; CAD02490.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO68438.1; -; Genomic_DNA.
DR RefSeq; NP_456673.1; NC_003198.1.
DR RefSeq; WP_001197813.1; NZ_WSUR01000002.1.
DR AlphaFoldDB; Q8Z5F7; -.
DR SMR; Q8Z5F7; -.
DR STRING; 220341.16503354; -.
DR EnsemblBacteria; AAO68438; AAO68438; t0745.
DR KEGG; stt:t0745; -.
DR KEGG; sty:STY2340; -.
DR PATRIC; fig|220341.7.peg.2364; -.
DR eggNOG; COG0841; Bacteria.
DR HOGENOM; CLU_002755_1_1_6; -.
DR OMA; FIIPCFY; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.2090.10; -; 2.
DR HAMAP; MF_01423; MdtB; 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR022831; Multidrug-R_MdtB.
DR PANTHER; PTHR32063; PTHR32063; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82714; SSF82714; 2.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..1040
FT /note="Multidrug resistance protein MdtB"
FT /id="PRO_0000161826"
FT TRANSMEM 15..37
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 345..362
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 367..389
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 396..418
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 438..460
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 472..494
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 535..557
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 867..889
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 909..931
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 968..990
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 1000..1022
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
SQ SEQUENCE 1040 AA; 111855 MW; 95500A7D02BD244F CRC64;
MQVLPPGSTG GPSRLFILRP VATTLLMAAI LLAGIIGYRF LPVAALPEVD YPTIQVVTLY
PGASPDVMTS SVTAPLERQF GQMSGLKQMS SQSSGGASVV TLQFQLTLPL DVAEQEVQAA
INAATNLLPS DLPNPPIYSK VNPADPPIMT LAVTSNAMPM TQVEDMVETR VAQKISQVSG
VGLVTLAGGQ RPAVRVKLNA QAIAALGLTS ETVRTAITGA NVNSAKGSLD GPERAVTLSA
NDQMQSADEY RKLIIAYQNG APVRLGDVAT VEQGAENSWL GAWANQAPAI VMNVQRQPGA
NIIATADSIR QMLPQLTESL PKSVKVTVLS DRTTNIRASV RDTQFELMLA IALVVMIIYL
FLRNIPATII PGVAVPLSLI GTFAVMVFLD FSINNLTLMA LTIATGFVVD DAIVVIENIS
RYIEKGEKPL AAALKGAGEI GFTIISLTFS LIAVLIPLLF MGDIVGRLFR EFAVTLAVAI
LISAVVSLTL TPMMCARMLS RQSLRKQNRF SRACERMFDR VIASYGRGLA KVLNHPWLTL
SVAFATLLLS VMLWITIPKG FFPVQDNGII QGTLQAPQSS SYASMAQRQR QVAERILQDP
AVQSLTTFVG VDGANPTLNS ARLQINLKPL DARDDRVQQV ISRLQTAVAT IPGVALYLQP
TQDLTIDTQV SRTQYQFTLQ ATTLDALSHW VPKLQNALQS LPQLSEVSSD WQDRGLAAWV
NVDRDSASRL GISMADVDNA LYNAFGQRLI STIYTQANQY RVVLEHNTAS TPGLAALETI
RLTSRDGGTV PLSAIARIEQ RFAPLSINHL DQFPVTTFSF NVPEGYSLGD AVQAILDTEK
TLALPADITT QFQGSTLAFQ AALGSTVWLI VAAVVAMYIV LGVLYESFIH PITILSTLPT
AGVGALLALI IAGSELDIIA IIGIILLIGI VKKNAIMMID FALAAEREQG MSPRDAIFQA
CLLRFRPILM TTLAALLGAL PLMLSTGVGA ELRRPLGIAM VGGLLVSQVL TLFTTPVIYL
LFDRLSLYVK SRFPRHKEEA
