ID   MDTB_SERP5              Reviewed;        1039 AA.
AC   A8GHQ9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Multidrug resistance protein MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
DE   AltName: Full=Multidrug transporter MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
GN   Name=mdtB {ECO:0000255|HAMAP-Rule:MF_01423}; OrderedLocusNames=Spro_3553;
OS   Serratia proteamaculans (strain 568).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=399741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=568;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L.,
RA   Vangronsveld J., van der Lelie D., Richardson P.;
RT   "Complete sequence of chromosome of Serratia proteamaculans 568.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtB forms a heteromultimer with MdtC. {ECO:0000255|HAMAP-
CC       Rule:MF_01423}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01423}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01423}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtB subfamily. {ECO:0000255|HAMAP-Rule:MF_01423}.
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DR   EMBL; CP000826; ABV42649.1; -; Genomic_DNA.
DR   RefSeq; WP_012146262.1; NC_009832.1.
DR   AlphaFoldDB; A8GHQ9; -.
DR   SMR; A8GHQ9; -.
DR   STRING; 399741.Spro_3553; -.
DR   EnsemblBacteria; ABV42649; ABV42649; Spro_3553.
DR   KEGG; spe:Spro_3553; -.
DR   eggNOG; COG0841; Bacteria.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; FIIPCFY; -.
DR   OrthoDB; 145346at2; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01423; MdtB; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR022831; Multidrug-R_MdtB.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1039
FT                   /note="Multidrug resistance protein MdtB"
FT                   /id="PRO_1000068505"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        342..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        440..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        472..492
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        537..557
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        863..883
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        888..908
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        911..931
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        968..988
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        1002..1022
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
SQ   SEQUENCE   1039 AA;  111988 MW;  3617E66C89F202D1 CRC64;
     MQVMPPNPGG GPSRLFILRP VATTLLMVAI LLAGIIGYRA LPVSALPEVD YPTIQVVTLY
     PGASPDVVTS AITAPLERQF GQMSGLKQMA SQSSGGASVV TLQFQLELPL DVAEQEVQAA
     INSATNLLPS DLPYPPIYSK VNPADPPILT LAVTSSAMPM TQVEDMVETR VAQKISQVTG
     VGLVTISGGQ RPAVRVKLNA AAVAAYGLDS ETIRTAISNA NVNSAKGSLD GPTRSVTLSA
     NDQMKSADDY RQLIVAYQNG AAIRLQDIAT IEQGAENTRL AAWANKQPAI VLNIQRQPGV
     NVITTADSIR EMLPQLIKSL PKSVDVKVLT DRTTTIRASV SDVQFELLLA VALVVMVIYV
     FLRNVPATII PSVAVPLSLI GTFAAMYFLG FSINNLTLMA LTIATGFVVD DAIVVIENIS
     RYIEKGEKPL DAALKGAGEI GFTIISLTFS LVAVLIPLLF MGDIVGRLFR EFAVTLAVAI
     LISAVVSLTL TPMMCARMLS HESLRKQNRF SAASERFFDR VIARYGKWLK TVLNHPWLTL
     GVAFSTLLLT VLLYLLIPKG FFPVQDNGII QGTLEAPQSV SFSNMAERQQ QVAAEILKDP
     AVESLTSFVG VDGTNATLNS GRLQINLKPL SERSERIPAI ITRLQQMSTQ FPGVKLYLQP
     VQDLTIDTQV SRTQYQFTLQ AMSLDDLSLW VPKLMAELQQ TPQLADVTSN WQDQGLVAYV
     NVDRDSASRL GISMSDVDNA LYNAFGQRLI STIYTQANQY RVVLEHDVST TPGLAALNDI
     RLTSSNGTIV PLSTIAKIEQ RFGPLSVNHL DQFPAATISF NVAGNYSLGE AVDAITLAEK
     NLNLPKDITT QFQGATLAFQ AALGGTLWLI LAAVVAMYIV LGVLYESFIH PVTILSTLPT
     AGVGALLALM MAGSELDVIA IIGIILLIGI VKKNAIMMID FALAAEREQG MTPYDAIYQA
     CLLRFRPILM TTLAALLGAL PLMLSTGVGA ELRHPLGVCM VGGLVMSQIL TLFTTPVIYL
     LFDKLARNTR RQPDAQELP