MDTB_XENBS
ID MDTB_XENBS Reviewed; 1056 AA.
AC D3V7P3;
DT 16-NOV-2011, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Multidrug resistance protein MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
DE AltName: Full=Multidrug transporter MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
GN Name=mdtB {ECO:0000255|HAMAP-Rule:MF_01423}; OrderedLocusNames=XBJ1_2731;
OS Xenorhabdus bovienii (strain SS-2004).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Xenorhabdus.
OX NCBI_TaxID=406818;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SS-2004;
RX PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C., de Leon L.,
RA Drace K., Du Z., Givaudan A., Herbert Tran E.E., Jewell K.A., Knack J.J.,
RA Krasomil-Osterfeld K.C., Kukor R., Lanois A., Latreille P.,
RA Leimgruber N.K., Lipke C.M., Liu R., Lu X., Martens E.C., Marri P.R.,
RA Medigue C., Menard M.L., Miller N.M., Morales-Soto N., Norton S.,
RA Ogier J.C., Orchard S.S., Park D., Park Y., Qurollo B.A., Sugar D.R.,
RA Richards G.R., Rouy Z., Slominski B., Slominski K., Snyder H., Tjaden B.C.,
RA van der Hoeven R., Welch R.D., Wheeler C., Xiang B., Barbazuk B.,
RA Gaudriault S., Goodner B., Slater S.C., Forst S., Goldman B.S.,
RA Goodrich-Blair H.;
RT "The entomopathogenic bacterial endosymbionts xenorhabdus and photorhabdus:
RT convergent lifestyles from divergent genomes.";
RL PLoS ONE 6:E27909-E27909(2011).
CC -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC MdtC. MdtB forms a heteromultimer with MdtC. {ECO:0000255|HAMAP-
CC Rule:MF_01423}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01423}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01423}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MdtB subfamily. {ECO:0000255|HAMAP-Rule:MF_01423}.
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DR EMBL; FN667741; CBJ81855.1; -; Genomic_DNA.
DR RefSeq; WP_012989141.1; NC_013892.1.
DR AlphaFoldDB; D3V7P3; -.
DR SMR; D3V7P3; -.
DR STRING; 406818.XBJ1_2731; -.
DR EnsemblBacteria; CBJ81855; CBJ81855; XBJ1_2731.
DR GeneID; 8832347; -.
DR KEGG; xbo:XBJ1_2731; -.
DR PATRIC; fig|406818.4.peg.2465; -.
DR eggNOG; COG0841; Bacteria.
DR HOGENOM; CLU_002755_1_2_6; -.
DR OMA; FIIPCFY; -.
DR Proteomes; UP000002045; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.2090.10; -; 2.
DR HAMAP; MF_01423; MdtB; 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR022831; Multidrug-R_MdtB.
DR PANTHER; PTHR32063; PTHR32063; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82714; SSF82714; 2.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1056
FT /note="Multidrug resistance protein MdtB"
FT /id="PRO_0000414031"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 537..557
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 869..889
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 890..910
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 911..931
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 968..988
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT TRANSMEM 1002..1022
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT REGION 1037..1056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1056 AA; 115246 MW; D87034ECF51BADBF CRC64;
MHSDSPMTGG GPSRLFILRP VATTLFMIAI LLAGIIGYRM LPVSALPQVD YPTIQVVTLY
PGASPDIMTS VVTAPLERQF GKISGLKQMT SQSSGGASVI TLVFQLSLPL DVAEQDVQAA
INAATNLLPN DLPYPPIYSK VNPADPPILT LAVTSDALPM IQVQDMVETR IAQRISQVGG
VGLVTLAGGQ RPAVRVKFNA QAIAAHGLNS ETIRTTIMNA NVSSAKGSFD GPTRSVTLTT
NDQMKSIDEY RNLIVAYKNG APIRLRDVAT IERGAENTKL GAWANEKPAI VINVQRQPGA
NVIDTTDNIR AMLPELINSL PKSVNMDILT DRTVTIRASV QDVQFELLLA IALVVMVIYV
FLRNATATLI PSIAVPLSLV GTFAVMYFCG FSVNNLTLMA LTIAAGFVVD DAIVVIENIS
RYIERGEKPM AAALKGAGEI GFTIISLTFS LIAVLIPLLF MGDIVGRLFR EFAITLAVAI
LISAVVSLTL TPMMCARMLK AEAEIKHNRF EQASEHFFER IIAIYGGWLK RVLNHPWITL
GVAFSTLAFT ALLYLTIPKG FFPLQDNGLI QGTLEAPQSI SFNAMSDKQR EVTALLLQDP
DVENVTTFIG VDGSNSTLNS GRLQITLKPL NQRDIRVDEI IPRLQARVAN VPDVKLYLQP
TQDLTIDTQV ARTQYQFTLQ GTVSNDLNIW VPKLQEALKQ RPELVDVGTD WQNRGLVAYI
NVNRDMASRL GISMTAIDNA LYNAFGQRLI STIYTQANQY RVILEQDTQN EAGMNAFNNV
HLIGTDNKVV PLSTIATVEQ QLGYLSINHL QQFPAVTFSF NVAQEASLEA AVNAVKETER
SIGMPKNINT QFQGATLAFQ DALGNTLWLI LAAVISMYIV LGILYESFIH PVTILSTLPT
AGVGALLALM VGGYELDIIA IIGIILLIGI VKKNAIMMID FALAAEREKG MSPYDAIFQA
CLLRFRPILM TTMAALLGAL PLMLSTGIGA ELRRPLGICM VGGLIMSQIL TLFTTPVIYL
LFDRLANYFK NKRQNRLQSQ NQRELDHSPV NHQEPL
