ID   MDTB_YERPE              Reviewed;        1052 AA.
AC   Q8ZCW0; Q0WD52; Q74SA7; Q7CJK9;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Multidrug resistance protein MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
DE   AltName: Full=Multidrug transporter MdtB {ECO:0000255|HAMAP-Rule:MF_01423};
GN   Name=mdtB {ECO:0000255|HAMAP-Rule:MF_01423};
GN   OrderedLocusNames=YPO2848, y1385, YP_2715;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtB forms a heteromultimer with MdtC. {ECO:0000255|HAMAP-
CC       Rule:MF_01423}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01423}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01423}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtB subfamily. {ECO:0000255|HAMAP-Rule:MF_01423}.
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DR   EMBL; AL590842; CAL21460.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM84957.1; -; Genomic_DNA.
DR   EMBL; AE017042; AAS62904.1; -; Genomic_DNA.
DR   PIR; AI0346; AI0346.
DR   RefSeq; WP_002209793.1; NZ_WUCM01000037.1.
DR   RefSeq; YP_002347786.1; NC_003143.1.
DR   AlphaFoldDB; Q8ZCW0; -.
DR   SMR; Q8ZCW0; -.
DR   IntAct; Q8ZCW0; 12.
DR   STRING; 214092.YPO2848; -.
DR   PaxDb; Q8ZCW0; -.
DR   DNASU; 1146332; -.
DR   EnsemblBacteria; AAM84957; AAM84957; y1385.
DR   EnsemblBacteria; AAS62904; AAS62904; YP_2715.
DR   GeneID; 57975806; -.
DR   KEGG; ype:YPO2848; -.
DR   KEGG; ypk:y1385; -.
DR   KEGG; ypm:YP_2715; -.
DR   PATRIC; fig|214092.21.peg.3292; -.
DR   eggNOG; COG0841; Bacteria.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; FIIPCFY; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IBA:GO_Central.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01423; MdtB; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR022831; Multidrug-R_MdtB.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1052
FT                   /note="Multidrug resistance protein MdtB"
FT                   /id="PRO_0000161829"
FT   TRANSMEM        15..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        345..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        367..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        396..418
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        438..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        472..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        535..557
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        867..889
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        909..931
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        968..990
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   TRANSMEM        1000..1022
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01423"
FT   REGION          1032..1052
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1052 AA;  113533 MW;  FFC2D74E485E2B61 CRC64;
     MQVMPPTPGG GPSRLFILRP VATTLFMIAI LLAGIIGYRA LPVSALPEVD YPTIQVVTLY
     PGASPDVVTS SITAPLERQF GQMSGLKQMA SQSSGGASVI TLQFQLTLPL DVAEQEVQAA
     INAATNLLPS DLPYPPIYNK VNPADPPILT LAVTATAIPM TQVEDMVETR IAQKISQVTG
     VGLVTLSGGQ RPAVRVKLNA PAVAALGLDS ETIRTAISNA NVNSAKGSLD GPTRSVTLSA
     NDQMKSAEEY RDLIIAYQNG APIRLQDVAT IEQGAENNKL AAWANTQSAI VLNIQRQPGV
     NVIATADSIR EMLPELIKSL PKSVDVKVLT DRTSTIRASV NDVQFELLLA IALVVMVIYL
     FLRNAAATII PSIAVPLSLV GTFAAMYFLG FSINNLTLMA LTIATGFVVD DAIVVIENIS
     RYIEKGEKPL DAALKGAGEI GFTIISLTFS LIAVLIPLLF MEDIVGRLFR EFAVTLAVAI
     LISAVVSLTL TPMMCARMLS YESLRKQNRL SRASEKFFDW VIAHYAVALK KVLNHPWLTL
     SVAFSTLVLT VILYLLIPKG FFPLQDNGLI QGTLEAPQSV SFSNMAERQQ QVAAIILKDP
     AVESLTSFVG VDGTNATLNN GRLQINLKPL SERDDRIPQI ITRLQESVSG VPGIKLYLQP
     VQDLTIDTQL SRTQYQFTLQ ATSLEELSTW VPKLVNELQQ KAPFQDVTSD WQDQGLVAFV
     NVDRDSASRL GITMAAIDNA LYNAFGQRLI STIYTQSNQY RVVLEHDVQA TPGLAAFNDI
     RLTGIDGKGV PLSSIATIEE RFGPLSINHL NQFPSATVSF NLAQGYSLGE AVAAVTLAEK
     EIQLPADITT RFQGSTLAFQ AALGSTLWLI IAAIVAMYIV LGVLYESFIH PITILSTLPT
     AGVGALLALM LTGNELDVIA IIGIILLIGI VKKNAIMMID FALAAERDQG MTPYDAIYQA
     CLLRFRPILM TTLAALFGAL PLMLSTGVGA ELRQPLGVCM VGGLIVSQVL TLFTTPVIYL
     LFDKLARNTR GKNRHRDEDI DSSELLNGQE PQ