ID   MDTC_CROS8              Reviewed;        1029 AA.
AC   A7MHJ0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE   AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN   Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424}; OrderedLocusNames=ESA_01142;
OS   Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Cronobacter.
OX   NCBI_TaxID=290339;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-894;
RX   PubMed=20221447; DOI=10.1371/journal.pone.0009556;
RA   Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L.,
RA   Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A.,
RA   Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K.,
RA   McClelland M., Forsythe S.J.;
RT   "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic
RT   hybridization analysis with other Cronobacter species.";
RL   PLoS ONE 5:E9556-E9556(2010).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
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DR   EMBL; CP000783; ABU76409.1; -; Genomic_DNA.
DR   RefSeq; WP_012124311.1; NC_009778.1.
DR   AlphaFoldDB; A7MHJ0; -.
DR   SMR; A7MHJ0; -.
DR   EnsemblBacteria; ABU76409; ABU76409; ESA_01142.
DR   KEGG; esa:ESA_01142; -.
DR   PATRIC; fig|290339.8.peg.1012; -.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; WRGVRTD; -.
DR   OrthoDB; 145346at2; -.
DR   Proteomes; UP000000260; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01424; MdtC; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR023931; Multidrug-R_MdtC.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1029
FT                   /note="Multidrug resistance protein MdtC"
FT                   /id="PRO_1000024313"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        469..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        528..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        853..873
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        897..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        953..973
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        984..1004
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ   SEQUENCE   1029 AA;  111146 MW;  58A64B30382C6B5C CRC64;
     MKFYALFIYR PVATILLSIA VTLCGVLGFR LLPVAPLPQV DFPVIMVSAS LPGASPETMA
     SSVATPLERS LGRIAGVNEM TSTSSLGSTR IILEFNFDRD INGAARDVQA AINAAQSLLP
     SGMPSRPTYR KANPSDAPIM ILTLTSDTFS QGELYDYAST QLAQTIAQID GVGDVDVGGS
     SLPAVRVALN PQALFNQGVS LDTVRSAISN ANVRRPQGAI EDAQRRWQLQ TNDELKTAAE
     YEPLIVHYNN GAAVHLRDVA TVTDSVQDVR NAGMTNAKPA ILLMIRKLPE ANIIETVDRI
     RAALPELRDT IPAAIDMQIA QDRSPTIRAS LAEVEQSLAI SVGLVILVVF LFLRSGRATL
     IPAVAVPVSL IGTFAAMYLC GFSLNNLSLM ALTIATGFVV DDAIVALENI SRHLEAGVKP
     LQAALQGVRE VGFTVLSMSL SLVAVFLPLL LMGGLPGRLF REFAVTLSVA IGISLVVSLT
     LTPMMCGWLL KAKPSEETRS RVGINRLLLA LQGGYARSLG WVLNHARLVG LVLLATIALN
     VWLYISIPKT FFPEQDTGRL MGGIQADQSI SFQAMRGKLQ DFMKIIREDP AVDNVTGFTG
     GSRVNSGMMF ISLKPLGERT ESAQQVIDRL RKKLAREPGA SLFLMAVQDI RVGGRQSNAS
     YQYTLLSDDL AALREWEPKI RQALAKLPQL ADVNSDQQDN GAEMSLVYDR ESMARLGISV
     QDANSLLNNA FGQRQISTIY QPLNQYKVVM EVDPRYTQDI SALDQMFVMN SEGKPIPLSW
     FAKWQPANAP LSVNHQGLSA ASTIAFNLPT GVSLSEASDA ITRTMTSLGV PSSVRGSFAG
     TAQVFQETMN SQVILILAAI ATVYIVLGML YESYVHPLTI LSTLPSAGVG ALLALEAFDA
     PFSLIALIGI MLLIGIVKKN AIMMVDFALE AQRSGQLSAR DAIFQACLLR FRPIMMTTLA
     ALFGALPLMI ASGDGAELRQ PLGITIVGGL VMSQLLTLYT TPVVYLFFDR LRLRFTRRAK
     PEDTLTASE