ID   MDTC_EDWI9              Reviewed;        1026 AA.
AC   C5BHN3;
DT   16-NOV-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE   AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN   Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424}; OrderedLocusNames=NT01EI_1169;
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146;
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
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DR   EMBL; CP001600; ACR68377.1; -; Genomic_DNA.
DR   RefSeq; WP_015870552.1; NC_012779.2.
DR   AlphaFoldDB; C5BHN3; -.
DR   SMR; C5BHN3; -.
DR   STRING; 67780.B6E78_16165; -.
DR   EnsemblBacteria; ACR68377; ACR68377; NT01EI_1169.
DR   GeneID; 7960915; -.
DR   KEGG; eic:NT01EI_1169; -.
DR   PATRIC; fig|634503.3.peg.1059; -.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; WRGVRTD; -.
DR   OrthoDB; 145346at2; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01424; MdtC; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR023931; Multidrug-R_MdtC.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1026
FT                   /note="Multidrug resistance protein MdtC"
FT                   /id="PRO_0000414033"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        435..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        459..479
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        528..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        853..873
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        897..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        953..973
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        984..1004
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ   SEQUENCE   1026 AA;  110510 MW;  DA954A51D0FB5932 CRC64;
     MSGFALFINR PVATSLLALA ITLVGLLGLR LLPVAPLPQV DFPVIMVSAS LPGASAETMA
     ASVAMPLERA LGRIAGVNEM TSSSSLGTTR IILQFNLDRN IDGAARDVQA ALNAAQSLLP
     SGMPSRPSYR KANPSDAPIA ILTLTSAQYS QGDLYDLAST RLAQKIAQIN GVGDVSVSGS
     SLPAVRIDLN PDALFNQGTS LDTVRQAIAS ANVRRPLGAV ADDGRRWQVQ SNDALMTAQE
     YRPLIIRYRD GAPLRLQDVA RISDGVEDVR NAGMSNGQPA ILIMIRRSAD ANIIETVDRL
     RSDLPALQAL LPGGVSLDIA QDRTPTIRAS LREVEQSLAI AIALVILVVF LFLRSARATL
     IPAVTVPVSL IGTCAAIYLC GFSLNNLSLM ALTIASGFVV DDAIVVLENI ARHIEDGLSP
     HRAALAGVRE VGFTVFSISL SLAAVFIPLL FMGGIPGRLF HEFAITLSAS IAISLLIALT
     LTPMMCARLL RPRHTDGGMR PTALRRLSAL LQRGYALSLN WTLDHARWVL LTLLAVIGLN
     IWLYISIPKT FFPQQDTGRL MGFIQADQSI SFQAMRGKLQ DFMHIVRADP DVDNVTGFTG
     GTRVNSGMMF IALKPLGERK QDAQQVIARL RTRLSHEPGA NLFLMAVQDI RAGGRQGNAS
     YQYTLLSDDL AVLRHWEPQV RKALAALPQL TDVSTDQQDK GTEMLLTYDR PAMARLGIKV
     SEVNTLLSNA FGQRQISTLY QPLNQYHVVM EVDPRYAQDE RALDKMFIIN QAGQPIPLSG
     FASWLPANAP LSVNHQGLSA AATISFNLPP GGSLSDASDA IAHAMTALGT PPSLRGTFAG
     TALLFQQAQS SQLLLILAAI ATVYIVLGIL YESYIHPLTI LSTLPSAGVG ALLALMLFNA
     PFSLIALIGI MLLIGLVKKN AILLVDFALT AEREQHLSAR DAIYQACLLR FRPILMTTLA
     ALFGALPLAF SYGDGAELRQ PLGITIVGGL LVSQILTLYT TPVVYLYMEK LRARFSRQKA
     LPPLAY