ID   MDTC_ENT38              Reviewed;        1025 AA.
AC   A4WCC2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE   AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN   Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424}; OrderedLocusNames=Ent638_2686;
OS   Enterobacter sp. (strain 638).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter.
OX   NCBI_TaxID=399742;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=638;
RX   PubMed=20485560; DOI=10.1371/journal.pgen.1000943;
RA   Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D.,
RA   Vangronsveld J., Newman L., Monchy S.;
RT   "Genome sequence of the plant growth promoting endophytic bacterium
RT   Enterobacter sp. 638.";
RL   PLoS Genet. 6:E1000943-E1000943(2010).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
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DR   EMBL; CP000653; ABP61352.1; -; Genomic_DNA.
DR   RefSeq; WP_015959685.1; NC_009436.1.
DR   AlphaFoldDB; A4WCC2; -.
DR   SMR; A4WCC2; -.
DR   STRING; 399742.Ent638_2686; -.
DR   EnsemblBacteria; ABP61352; ABP61352; Ent638_2686.
DR   KEGG; ent:Ent638_2686; -.
DR   eggNOG; COG0841; Bacteria.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; WRGVRTD; -.
DR   OrthoDB; 145346at2; -.
DR   Proteomes; UP000000230; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01424; MdtC; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR023931; Multidrug-R_MdtC.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1025
FT                   /note="Multidrug resistance protein MdtC"
FT                   /id="PRO_1000068508"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        528..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        853..873
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        875..895
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        897..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        953..973
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        984..1004
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ   SEQUENCE   1025 AA;  110886 MW;  9EF8D8F1198CBD95 CRC64;
     MKFFALFIYR PVATILIAVA ITLCGVLGFR LLPVAPLPQV DFPVIMISAS LPGASPETMA
     SSVATPLERS LGRIAGVNEM TSSSSLGSTR IILEFNFNRD INGAARDVQA AINAAQSLLP
     SGMPSRPTYR KANPSDAPIM ILTLTSDTYS QGELYDFAST QLAQTIAQID GVGDVDVGGS
     SLPAVRVGLN PEALFNQGVS LDDVRSAISN ANVRKPQGAI EDSSHRWQIQ TNDELKTAAE
     YQPLIIHYNN GAAVRLSDVA SVTDSVQDVR NAGMTNAKPA ILLMIRKLPE ANIIQTVNSI
     RARLPELQET IPAAIDLQIA QDRSPTIRAS LEEVEQTLVI SIALVILVVF LFLRSGRATL
     IPAVAVPVSL IGTFAAMYLC GFSLNNLSLM ALTIATGFVV DDAIVVLENI SRHLEAGMKP
     LQASLQGTRE VGFTVLSMSV SLVAVFLPLL LMGGLPGRLL REFAVTLSVA IGISLVISLT
     LTPMMCGWML KRSKPHSQPR NKGFGRVLVA MQEGYGKSLK WVLNHTRIVG LVLVGTIALN
     VWMYITIPKT FFPEQDTGVL MGGIQADQSI SFQAMRVKLQ DFMKIIREDP AVDNVTGFTG
     GSRVNSGMMF ITLKARGERN ETAQQVIDRL RGKLAKEPGA NLFLMAVQDI RVGGRQSNAS
     YQYTLLSDDL AALREWEPKI RKALAAMPEL ADVNSDQQDN GAEMNLTYDR ETMSRLGIDV
     AAANSLLNNA FGQRQISTIY QPMNQYKVVM EVDPRYTQDI SALDKMYVIN NDGKSIPLSY
     FASWQPANAP LSVNHQGLSA ASTISFNLPT GSSLSEASDA INRTMTQLGV PSTVRGSFAG
     TAQVFQDTMN SQVILILAAI ATVYIVLGIL YESYVHPLTI LSTLPSAGVG ALLALELFDA
     PFSLIALIGI MLLIGIVKKN AIMMVDFALD AQRNGNMSPQ DAIFQACILR FRPIMMTTLA
     ALFGALPLVI SSGDGSELRQ PLGITIVGGL AMSQLLTLYT TPVVYLFFDR LRVRFSRKNR
     TTVTE