ID   MDTC_ERWAE              Reviewed;        1024 AA.
AC   D4I6V4;
DT   16-NOV-2011, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE   AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN   Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424}; OrderedLocusNames=EAM_2185;
OS   Erwinia amylovora (strain ATCC 49946 / CCPPB 0273 / Ea273 / 27-3).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Erwinia.
OX   NCBI_TaxID=716540;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49946 / CCPPB 0273 / Ea273 / 27-3;
RX   PubMed=20118253; DOI=10.1128/jb.00022-10;
RA   Sebaihia M., Bocsanczy A.M., Biehl B.S., Quail M.A., Perna N.T.,
RA   Glasner J.D., DeClerck G.A., Cartinhour S., Schneider D.J., Bentley S.D.,
RA   Parkhill J., Beer S.V.;
RT   "Complete genome sequence of the plant pathogen Erwinia amylovora strain
RT   ATCC 49946.";
RL   J. Bacteriol. 192:2020-2021(2010).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
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DR   EMBL; FN666575; CBJ46859.1; -; Genomic_DNA.
DR   RefSeq; WP_004158348.1; NC_013971.1.
DR   AlphaFoldDB; D4I6V4; -.
DR   SMR; D4I6V4; -.
DR   GeneID; 8914524; -.
DR   KEGG; eay:EAM_2185; -.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; WRGVRTD; -.
DR   BioCyc; EAMY716540:EAM_RS10580-MON; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01424; MdtC; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR023931; Multidrug-R_MdtC.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1024
FT                   /note="Multidrug resistance protein MdtC"
FT                   /id="PRO_0000414034"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        528..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        853..873
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        875..895
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        897..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        953..973
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        984..1004
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ   SEQUENCE   1024 AA;  110892 MW;  324369485B6AF4DA CRC64;
     MKFLSLFIYR PVATSLLTLA LVLSGLLGFR MLPVASLPQM DFPVIVVSAS LPGASPETMA
     SSVATPLERA LGRIAGVSEM TSSSSLGSTE VVLMFDFDRD INGAARDVQG AINAAQSLLP
     SGMPRRPSYR KVNPSDAPIM IMTLSSDTFS PGQLYDYAST QLAQRLSQID GVGDVTIGGS
     SLPAVRVDLN PQALFNQGVS LDAVRTTIAN ANVRRPQGAI DDRQQRWWLK TNDELHTAAE
     YRPLVIRYHQ GAAVRLQDVA TVTDSVENVR NAGMSNARPA VLVVIRKSPQ ANVIDTIDRI
     RDEVPQLRKT IPAAIQLEIA QDSSATIRAS LHEVEQSLAV SVGLVVLVVF AFLRSGRATL
     IPAVAVPVSL IGTFAAMYLC GFSLNNLSLM ALTVASGFVV DDAIVVLENI SRHVEAGLKP
     LQAALLGGRE VGFTVVSMSV SLIAVFIPLL MQGGIIGRFF REFAITLSVS IAISLVISLT
     LTPVMCARLL RSSAPRQQPR RRGFGRMLLV VQQGYGRALH RVLDHARWAL LVFVASLGLT
     VYLFISMPKT FMPEQDTGRL MGFIQADQST SFQAMRSKVE HFMRVVHADP AVESVVGFTG
     GWETNSGAMF IALKPLSTRG DNAQQVIARL RSKLAKEAGA TLWLRAVQDI RIGARQSDGG
     YQYSLLSDSL DDLRQWQPKI RRAFASLPEL VDVNSDQQDK GAEMALTYDR TRMARLGIDV
     ADVNGLLNNA FGQRQISTIY QPLNQYQVVM GVDARYAQDI NALNQMYVTN HQGQPIPLSS
     FASWQPANAP LSVEHEGLSA VSTLSFNLPE GVSLSQAAAA IDRSVIALGM PSSVRGSFSG
     TAAVFEQTQS SQLWLILAAI ATVYIVLGML YESYVHPLTI LSTLPSAGMG ALLALKLFNT
     PFSLIALIGI LLLIGIVKKN AIMMVDFALQ AQRQDGMPVR EAIFQASLLR FRPIIMTTLA
     AMLGALPLVL SSGDGAELRQ PLGITIVGGL VVSQLLTLFT TPVVYLYMDK LRRKPRWRPV
     PAQS