ID   MDTC_ERWT9              Reviewed;        1024 AA.
AC   B2VFQ4;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE   AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN   Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424}; OrderedLocusNames=ETA_13100;
OS   Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB
OS   4357 / Et1/99).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Erwinia.
OX   NCBI_TaxID=465817;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99;
RX   PubMed=18462403; DOI=10.1111/j.1462-2920.2008.01639.x;
RA   Kube M., Migdoll A.M., Mueller I., Kuhl H., Beck A., Reinhardt R.,
RA   Geider K.;
RT   "The genome of Erwinia tasmaniensis strain Et1/99, a non-pathogenic
RT   bacterium in the genus Erwinia.";
RL   Environ. Microbiol. 10:2211-2222(2008).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
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DR   EMBL; CU468135; CAO96356.1; -; Genomic_DNA.
DR   RefSeq; WP_012441050.1; NC_010694.1.
DR   AlphaFoldDB; B2VFQ4; -.
DR   SMR; B2VFQ4; -.
DR   STRING; 465817.ETA_13100; -.
DR   EnsemblBacteria; CAO96356; CAO96356; ETA_13100.
DR   KEGG; eta:ETA_13100; -.
DR   eggNOG; COG0841; Bacteria.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; WRGVRTD; -.
DR   OrthoDB; 145346at2; -.
DR   Proteomes; UP000001726; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01424; MdtC; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR023931; Multidrug-R_MdtC.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1024
FT                   /note="Multidrug resistance protein MdtC"
FT                   /id="PRO_1000145674"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        528..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        853..873
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        897..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        953..973
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        984..1004
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ   SEQUENCE   1024 AA;  111048 MW;  7AEDA26D955A3B08 CRC64;
     MRFFSLFIHR PVATWLLTLT IVLAGFLGFR LLPVAPLPQV DFPVIVVTAS LPGASPEIMA
     SSVATPLERA LGRIAGVSEM TSSSSLGSTH VILLFDFDRD INGAARDVQG AINAAQSLLP
     SGMPNRPSYR KVNPSDAPIM IMTLTSDTYS PGQLYDYAST KLAQRLAQID GVGDVTVGGS
     SLPAVRVDLN PQALFNQGVS LDAVRSTIAN ANVRKPQGAI EDSQLRWWIK TNDELHTAAE
     YRPLVIHYRN GAAVRLQDVA TVTDSVQDVR NAGMSNARPA VLLVIRKSPQ ANIIDTVDRI
     RGEVPELRNT LPASIGLDIA QDSSRTIRAS LHEVEQSLAI SVGLVVLVVF AFLRSGRATL
     IPAVAVPVSL IGTFAAMYLC GFSLNNLSLM ALTVATGFVV DDAIVVLENI SRHVEAGMKP
     LLAALKGVRE VGFTVISMSI SLVAVFLPLL LMDGIIGRFF KEFAITLSVS IAISLVISLT
     LTPMMCARLL RPNAPRQQPR LRGFGRILMA IQRGYGRGLH WVLDHARWGL LVFVATLGLT
     VYLYISIPKT FMPEQDTGRL MGFIQADQSI SFQAMRGKLE TFMRIVRDDP AVESVVGFTG
     GSDTNSGSMF IALKPLSARS DNAQQVISRL REKLTKEPGA NLWLMAVQDI RIGARQSNAG
     YQYSLLSDSL DDLRQWEPKI RRAFSALPEL VDVNSDQQDK GAEMALTYDR TSMARLGIDV
     ADVNDLLNNA FGQRQISTIY QPLNQYKVVM GVDPRYSQDI SALNQMYLIN KEGRSIPLSA
     FAKWQPANAP LSVEHEGLSA ASTISFNLPE GVSLSQASAA IERSVTSLGV PASVRGSFSG
     TAAVFEQTQS SQLWLILAAI ATVYIVLGIL YESYVHPLTI LSTLPSAGVG ALLALELFNA
     PFSLIALIGI LLLIGIVKKN AIMMVDFALQ AQRQEGMTAR EAIFQASLLR FRPIIMTTLA
     ALLGALPLAL GSGDGAELRQ PLGITIVGGL VMSQLLTLFT TPVVYLYMDK LRRRPRWLPV
     EEKS