ID   MDTC_KLEP7              Reviewed;        1025 AA.
AC   A6TBH5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE   AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN   Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN   OrderedLocusNames=KPN78578_24850; ORFNames=KPN_02528;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
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DR   EMBL; CP000647; ABR77946.1; -; Genomic_DNA.
DR   RefSeq; WP_002912617.1; NC_009648.1.
DR   AlphaFoldDB; A6TBH5; -.
DR   SMR; A6TBH5; -.
DR   STRING; 272620.KPN_02528; -.
DR   EnsemblBacteria; ABR77946; ABR77946; KPN_02528.
DR   KEGG; kpn:KPN_02528; -.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; WRGVRTD; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01424; MdtC; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR023931; Multidrug-R_MdtC.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1025
FT                   /note="Multidrug resistance protein MdtC"
FT                   /id="PRO_1000024314"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        469..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        528..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        851..871
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        875..895
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        897..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        953..973
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        984..1004
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ   SEQUENCE   1025 AA;  110637 MW;  62BC9215759F4757 CRC64;
     MKFFALFIYR PVATILISLA ITLCGILGFR LLPVAPLPQV DFPVIMVSAS LPGASPETMA
     SSVATPLERS LGRIAGVNEM TSSSSLGSTR IILEFNFDRD INGAARDVQA AINAAQSLLP
     SGMPSRPTYR KANPSDAPIM ILTLTSDTYS QGELYDFAST QLAQTIAQID GVGDVDVGGS
     SLPAVRVDLN PQALFNQGVS LDAVRTAISD ANVRKPQGAL EDSAHRWQVQ TNDELKTAAD
     YQPLIVHYQN GAAVRLGDVA TVSDSVQDVR NAGMTNAKPA ILLMIRKLPE ANIIQTVDSI
     RARLPELQQT IPAAIDLQIA QDRSPTIRAS LEEVEQTLVI SVALVILVVF LFLRSGRATL
     IPAVAVPVSL IGTFAAMYLC GFSLNNLSLM ALTIATGFVV DDAIVVLENI SRHLEAGMKP
     LQAALQGSRE VGFTVLSMSL SLVAVFLPLL LMGGLPGRLL REFAVTLSVA IGISLAVSLT
     LTPMMCGWLL KSGKPHQPTR NRGFGRLLVA VQGGYGKSLK WVLKHSRLTG LVVLGTIALS
     VWLYISIPKT FFPEQDTGVL MGGIQADQSI SFQAMRGKLQ DFMKIIREDP AVDNVTGFTG
     GSRVNSGMMF ITLKPRDQRH ETAQQVIDRL RKKLANEPGA NLFLMAVQDI RVGGRQSNAS
     YQYTLLSDDL SALREWEPKI RKALAALPEL ADVNSDQQDN GAEMDLVYDR DTMSRLGISV
     QDANNLLNNA FGQRQISTIY QPLNQYKVVM EVDPAYTQDV SALDKMFVIN SDGKPIPLAY
     FAKWQPANAP LSVNHQGLSA ASTISFNLPT GRSLSEASEA IDRAMTQLGV PSSVRGSFAG
     TAQVFQQTMN AQVILILAAI ATVYIVLGVL YESYVHPLTI LSTLPSAGVG ALLALEIFDA
     PFSLIALIGI MLLIGIVKKN AIMMVDFALE AQRNGNLTPE EAIFQACLLR FRPIMMTTLA
     ALFGALPLVL SGGDGSELRQ PLGITIVGGL VMSQLLTLYT TPVVYLFFDR LRLRFSRHSS
     QPVSE