ID   MDTC_PANAA              Reviewed;        1025 AA.
AC   F2EYE0;
DT   16-NOV-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 2.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE   AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN   Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424}; OrderedLocusNames=PAJ_1810;
OS   Pantoea ananatis (strain AJ13355).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Pantoea.
OX   NCBI_TaxID=932677;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AJ13355;
RX   PubMed=22159605; DOI=10.1007/s00253-011-3713-5;
RA   Hara Y., Kadotani N., Izui H., Katashkina J.I., Kuvaeva T.M.,
RA   Andreeva I.G., Golubeva L.I., Malko D.B., Makeev V.J., Mashko S.V.,
RA   Kozlov Y.I.;
RT   "The complete genome sequence of Pantoea ananatis AJ13355, an organism with
RT   great biotechnological potential.";
RL   Appl. Microbiol. Biotechnol. 93:331-341(2012).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAK11890.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AP012032; BAK11890.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_028715330.1; NC_017531.2.
DR   AlphaFoldDB; F2EYE0; -.
DR   SMR; F2EYE0; -.
DR   STRING; 932677.PAJ_1810; -.
DR   EnsemblBacteria; BAK11890; BAK11890; PAJ_1810.
DR   KEGG; paj:PAJ_1810; -.
DR   PATRIC; fig|932677.3.peg.2114; -.
DR   eggNOG; COG0841; Bacteria.
DR   HOGENOM; CLU_002755_1_1_6; -.
DR   BioCyc; PANA932677:PAJ_RS10025-MON; -.
DR   Proteomes; UP000006690; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01424; MdtC; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR023931; Multidrug-R_MdtC.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1025
FT                   /note="Multidrug resistance protein MdtC"
FT                   /id="PRO_0000414035"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        459..479
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        528..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        853..873
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        875..895
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        897..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        953..973
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        984..1004
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ   SEQUENCE   1025 AA;  110488 MW;  49B339EA22C64D77 CRC64;
     MKFFALFIHR PVATTLLTLA IALAGILGFR LLPVAPLPQV DFPVIMVSAS LPGASPETMA
     SSVATPLERS LGRIAGVSEM TSTSSLGSTR IIMVFDFDRD INGAARDVQA AINAAQSLLP
     TGMPSRPTYR KANPSDAPIM IMTLTSDLYS PAQLYDYAST QLAQKLSQIN GVGDVTVGGS
     SLPAVRVALN PQALFNQGVS LDAVRQTISN ANQRRPQGAV EDGQQRWQLR TNDALQTASE
     YQPLVVHYNN GAAVRLSDVA TVQDSVQDVR NAGMSRGKPA VLLVIRKTAD ANVIETVDRI
     RAELPELHEI IPAAINLEVA QDRSPTIRAS LEEVEQSLMI AVALVILVVF VFLRSGRATL
     IPAVAVPVSL IGTFAAMYLC GFSLNNLSLM ALTIATGFVV DDAIVVLENI ARHVEAGMKP
     MAAALKGVRE VGFTVLSMSL SLIAVFLPLL MTGGLIGRFF AEFSITLSVA ILISLFVSVT
     LTPMMCAYLL KPHAPRSQPQ RRGVGRLLLA VQRGYARSLT VVLNHARWVL LLLLGTVALT
     VWLFISIPKT FLPEQDTGRL SGFISADQSI SFQAMRGKLE DFMKIVGADP DVSSVVGFTG
     GMRTNMGLMF ISLKPLSERK DTAQAVIARL RAKLANEPGA NLYLNAVQDI RVGGREANAS
     YQYSLLSDDL AALRTWEPKI RQAFTALPEL ADVNSDQQDK GSEMALTYDR ASMARLGINV
     SEANALLNDA FGQRQISTIY QPLNQYKVVM EVDPRYTQDI SALNQMFVIN SEGKPIPLAW
     FAKWQPANAP LSVNHEGLSA ASTISFNLPE GVSLSQASEA IERTMTALGV PSSVRGSFAG
     TAQAFQQSQS SQLWLMLAAI AAVYIVLGIL YESYVHPLTI LSTLPSAGVG ALLALALFDT
     PFSLIALIGI LLLIGIVKKN AIMMVDFALE AERNGNLSPR DAIFQACLLR FRPILMTTLA
     ALFGALPLVL TSGDGAELRQ PLGITIAGGL IMSQLLTLYT TPVVYLMMDK LRRKKRTQTI
     NATQH