MDTC_PECAS
ID MDTC_PECAS Reviewed; 1026 AA.
AC Q6D2B0;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424}; OrderedLocusNames=ECA3186;
OS Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS carotovora subsp. atroseptica).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Pectobacteriaceae; Pectobacterium.
OX NCBI_TaxID=218491;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCRI 1043 / ATCC BAA-672;
RX PubMed=15263089; DOI=10.1073/pnas.0402424101;
RA Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J.,
RA Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K.,
RA Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J.,
RA Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Norbertczak H.,
RA Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S.,
RA Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K.;
RT "Genome sequence of the enterobacterial phytopathogen Erwinia carotovora
RT subsp. atroseptica and characterization of virulence factors.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004).
CC -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC Rule:MF_01424}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01424}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
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DR EMBL; BX950851; CAG76084.1; -; Genomic_DNA.
DR RefSeq; WP_011094708.1; NC_004547.2.
DR AlphaFoldDB; Q6D2B0; -.
DR SMR; Q6D2B0; -.
DR STRING; 218491.ECA3186; -.
DR PRIDE; Q6D2B0; -.
DR EnsemblBacteria; CAG76084; CAG76084; ECA3186.
DR GeneID; 57209871; -.
DR KEGG; eca:ECA3186; -.
DR PATRIC; fig|218491.5.peg.3227; -.
DR eggNOG; COG0841; Bacteria.
DR HOGENOM; CLU_002755_1_2_6; -.
DR OMA; WRGVRTD; -.
DR OrthoDB; 145346at2; -.
DR Proteomes; UP000007966; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.2090.10; -; 2.
DR HAMAP; MF_01424; MdtC; 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR023931; Multidrug-R_MdtC.
DR PANTHER; PTHR32063; PTHR32063; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82714; SSF82714; 2.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1026
FT /note="Multidrug resistance protein MdtC"
FT /id="PRO_0000161834"
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 336..353
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 360..382
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 431..450
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 463..485
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 525..547
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 853..875
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 895..917
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 948..970
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 985..1007
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ SEQUENCE 1026 AA; 110811 MW; FAFDAD8AE4F173FF CRC64;
MKFFALFIHR PVATLLLTLA IALCGVLGFR LLPVSPLPQV DFPVISVSAS LAGASPETMA
SAVATPLERA LGRIAGVSEM TSTSSLGSTR VILVFNLDRD INGAARDVQA AINAAQNLLP
SGMSSRPTYR KVNPSDAPVM ILTLTSDTYS QGQLYDFAST QLSQKISQME GVGDVSIGGS
SLPAVRVALN PVALFNQGIS LDEVRQAIAQ ANVRQPLGNV ENSQKRWQIQ TNDELKTADA
YAPLIIHYSN GAAVRLSDVA TVEDSVQNSR NAGMANSKPA ILVMIRRAPD ANIITTVDNI
RAAMPELRAS LPAEIQLDVA QDRSPTIRAS LAEVEQSLII AVALVILVVF LFLRSWRATA
IPALAVPVSL IGTFAAMYLC GFSLNNLSLM ALTIATGFVV DDAIVVLENI SRHIEAGMKP
LQASLQGVRE VGFTVLSMSL SLVAVFLPLL LMDGLPGRLF REFAVTLSVA IMISLLISLT
LTPMLCARLL RAVPKRSQPR TQGFNRVLLA MQQGYGRSLK WVLNHARWVL LLLLGTIALN
VWLYISIPKT FFPEQDTGRM MGFIQADQSI SFQAMTVKLQ NFMTIVSSDP AVDNVNGFTG
GSRTNSGSMF ISLKPLSERD VSAQQVISRL RIKLAKEPGA NLFLMPVQDI RIGGREANAG
YQYTLLSDDL NELRTWEPKI RAAFSKLPEL ADVNSDQQDK GAEMALTYDR DAMAQLGISV
SAANALLNNA FGQRQISTIY QPLNQYKVVM EVDDAYTQDV SSLDKMFVIN SDNKPIPLSY
FASWKPINAP LSVNHQGLSA ASTISFNLPE GTDLSSATAA IERTMTSLGV PSSVRGQFSG
TAQAFQQSQS SQLLLILAAI ITVYIVLGIL YESYVHPLTI LSTLPSAGVG ALLALEWFGA
PFSLVALIGI MLLIGIVKKN AIMMVDFALV AQRSGKLSAQ DAIFQACLLR FRPIMMTTLA
ALFGALPLVL TSGDGAELRQ PLGITIVGGL LMSQVLTLYT TPVVYLFFDK LRTIRRKAPE
KDLSLS
