ID   MDTC_PECCP              Reviewed;        1026 AA.
AC   C6DBC8;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE   AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN   Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424}; OrderedLocusNames=PC1_2968;
OS   Pectobacterium carotovorum subsp. carotovorum (strain PC1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=561230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PC1;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C.,
RA   Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Balakrishnan V., Glasner J., Perna N.T.;
RT   "Complete sequence of Pectobacterium carotovorum subsp. carotovorum PC1.";
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
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DR   EMBL; CP001657; ACT13991.1; -; Genomic_DNA.
DR   RefSeq; WP_015841146.1; NC_012917.1.
DR   AlphaFoldDB; C6DBC8; -.
DR   SMR; C6DBC8; -.
DR   STRING; 561230.PC1_2968; -.
DR   EnsemblBacteria; ACT13991; ACT13991; PC1_2968.
DR   KEGG; pct:PC1_2968; -.
DR   eggNOG; COG0841; Bacteria.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; WRGVRTD; -.
DR   OrthoDB; 145346at2; -.
DR   Proteomes; UP000002736; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01424; MdtC; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR023931; Multidrug-R_MdtC.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1026
FT                   /note="Multidrug resistance protein MdtC"
FT                   /id="PRO_1000215263"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        528..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        853..873
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        875..895
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        897..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        953..973
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        984..1004
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ   SEQUENCE   1026 AA;  110613 MW;  7F527098EF3C0AC5 CRC64;
     MKFFALFIHR PVATLLLTLA IALCGVLGFR LLPVSPLPQV DFPVISVSAS LPGASPETMA
     SAVATPLERA LGRIAGVSEM TSTSSLGSTR VILVFNLDRD INGAARDVQA AINAAQNLLP
     SGMSSRPTYR KVNPSDAPVM ILTLTSDTYS QGQLYDFAST QLSQKISQME GVGDVSIGGS
     SLPAVRVALN PVALFNQGIS LDEVRQAIAQ ANVRQPLGNV ENSQKSWQIK TNDELKTADA
     YAPLIIHYNN GAAVRLSDVA TVEDSVQNSR NAGMANAKPA ILVMIRRAPD ANIITTVDNI
     RAAMPELRAS LPAEIQLDVA QDRSPTIRAS LAEVEQSLVI AVALVILVVF LFLRSGRATA
     IPALAVPVSL IGTFAAMYLC GFSLNNLSLM ALTIATGFVV DDAIVVLENI SRHIEAGMKP
     LQASLQGVRE VGFTVLSMSL SLVAVFIPLL LMEGLPGRLF REFAVTLSVA IMISLLISLT
     LTPMLCARLL RAVPKRSQPR KQGFNRVLLA MQQGYGRSLK WVLNHARWVL LLLLGTIALN
     VWLYISIPKT FFPEQDTGRL MGFIQADQSI SFQAMTVKLQ NFMTIVSSDP AVDNVNGFTG
     GSRTNSGSMF ISLKPLSERD VSAQQVISRL RIKLAKEPGA NLFLMPVQDI RIGGREANAG
     YQYTLLSDDL SELRTWEPKI RAAFSKLPEL ADVNSDQQDK GAEMALTYDR DAMAQLGISV
     SAVNALLNNA FGQRQISTIY QPLNQYKVVM EVDDAYTQDV SSLNKMFVIN SEGKPIPLSY
     FASWKPINAP LSVNHQGLSA ASTISFNLPE GTDLSSATAA IERTMTSLGV PSAVRGQFSG
     TAQAFQQSQS SQLLLILAAI ITVYIVLGVL YESYVHPLTI LSTLPSAGVG ALLALEWFGA
     PFSLVALIGI MLLIGIVKKN AIMMVDFALV AQRSGKLSAQ DAIFQACLLR FRPIMMTTLA
     ALFGALPLVL TSGDGAELRQ PLGITIVGGL VMSQILTLYT TPVVYLFFDK LRNIRRKAPE
     RDVSLS