ID   MDTC_PHOLL              Reviewed;        1036 AA.
AC   Q7N3E1;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE   AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN   Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424}; OrderedLocusNames=plu2776;
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
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DR   EMBL; BX571868; CAE15150.1; -; Genomic_DNA.
DR   RefSeq; WP_011146996.1; NC_005126.1.
DR   AlphaFoldDB; Q7N3E1; -.
DR   SMR; Q7N3E1; -.
DR   STRING; 243265.plu2776; -.
DR   EnsemblBacteria; CAE15150; CAE15150; plu2776.
DR   GeneID; 24170414; -.
DR   KEGG; plu:plu2776; -.
DR   eggNOG; COG0841; Bacteria.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; WRGVRTD; -.
DR   OrthoDB; 145346at2; -.
DR   BioCyc; PLUM243265:PLU_RS13770-MON; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01424; MdtC; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR023931; Multidrug-R_MdtC.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1036
FT                   /note="Multidrug resistance protein MdtC"
FT                   /id="PRO_0000161835"
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        336..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        360..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        431..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        463..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        528..547
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        853..875
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        895..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        949..971
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        986..1008
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ   SEQUENCE   1036 AA;  113287 MW;  CB514E898C644C28 CRC64;
     MKFFALFIQR PVATTLLSLA ITLCGVLGFT LLPVSPLPQV DFPVISVYAS LPGASPETMA
     SSVATPLEHA LGRIAGVNEM TSSSSLGSTN ITLEFDLNRD INSAARDVQA ALNAAQSLLP
     SGMPSRPHYY KVNPTDAPIM ILTLTSDTYN QGQLYDFAST QLAQKIAQVE GVSEVSVGGS
     SLPAVRVELN PGVLFHQGVS LDAVRKAISN ANVRRPQGYV DSEQQHWQIQ MNDELKTAEN
     YRPIIVHYNN NSPVRLQDVA NVKDSVQNVR AAGMSGGEPA ILLIIRREAG ANIIATVNRI
     REQLPALHES IPASIQLKVA QDRTPTIRAS IVEVERALVI AIGLVILVVF LFLRSGRATL
     IPAIAVPVSL IGTFTAMYLC GFSLNNLSLM ALTVATGFVV DDAIVVLENI SRHLEAGIKP
     MQAALQGVRE VGFTVLSMSI SLVAVFIPLL LMDGLVGRLF REFAITLTTS ISISLLVSLT
     LTPMMCAHLL KSQRPKAQKK IRGFGKVLLK IQQVYGRSLM WVLNHSRWVL LILAGIIALN
     VWLYINIPKT FFPEQDTGRL LGFVRADQSI SFQSMREKMK NFMQTINADP TVDSVIGFTG
     GGRVNNGFMF ISLKPLKERS ENAEQIISRL RIKLANEPGA NLFLIPVQDI RAGGRQANAS
     YQFTLLADDL NDLRKWEPVI RKALGQLPQL TDVNSDKEDK GAEMAIIYDR DTMSRLGINV
     SEANNLLNNA FGQRQISTIY QPLNQYKVVM EVAPEYTQDV SALEKMFVIN NQGKAIPLSY
     FAHWQPANAP LSVNHQGLSA ASTIAFNVPE GYTLSDAINA IERTTTELRV PSTVRGTFAG
     TAQIFQETLK SQLFLILAAI ITVYLVLGIL YESYIHPLTI LSTLPSAGIG ALLALELFDT
     PFSLIALIGI MLLIGIVKKN AIIMVDFAIE AQRNGNICAR DAIFQASLLR FRPILMTTLA
     ALFGSLPLVL SSGDGTELRQ PLGITIVGGL VMSQLLTLYT TPVVYLCFDR LRAYPNRRNC
     CRQFEHGQRG KTGTYT