ID   MDTC_PROMH              Reviewed;        1027 AA.
AC   B4EYA1;
DT   16-NOV-2011, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE   AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN   Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424}; OrderedLocusNames=PMI1587;
OS   Proteus mirabilis (strain HI4320).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Proteus.
OX   NCBI_TaxID=529507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HI4320;
RX   PubMed=18375554; DOI=10.1128/jb.01981-07;
RA   Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S.,
RA   Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T.,
RA   Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA   Rabbinowitsch E., Walker D., Whithead S., Thomson N.R., Rather P.N.,
RA   Parkhill J., Mobley H.L.T.;
RT   "Complete genome sequence of uropathogenic Proteus mirabilis, a master of
RT   both adherence and motility.";
RL   J. Bacteriol. 190:4027-4037(2008).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
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DR   EMBL; AM942759; CAR43321.1; -; Genomic_DNA.
DR   RefSeq; WP_004243447.1; NC_010554.1.
DR   AlphaFoldDB; B4EYA1; -.
DR   SMR; B4EYA1; -.
DR   STRING; 529507.PMI1587; -.
DR   PRIDE; B4EYA1; -.
DR   EnsemblBacteria; CAR43321; CAR43321; PMI1587.
DR   GeneID; 6802165; -.
DR   KEGG; pmr:PMI1587; -.
DR   eggNOG; COG0841; Bacteria.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; WRGVRTD; -.
DR   Proteomes; UP000008319; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01424; MdtC; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR023931; Multidrug-R_MdtC.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1027
FT                   /note="Multidrug resistance protein MdtC"
FT                   /id="PRO_0000414036"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        528..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        853..873
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        875..895
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        897..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        953..973
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        984..1004
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ   SEQUENCE   1027 AA;  111758 MW;  A6AB184A656FF4ED CRC64;
     MKLFALFIQR PVATTLLSLA ISLCGALGFM LLPVAPLPQV DYPVINIYAS LPGASPETMA
     SSVATPLERS LGRIAGIDEM TSSSALGSTS ITLVFDLNKD INTAARDVQA ALNASQSLLP
     SGMPSRPRYY KSNPSDAPIM ILTLTSETQN TGELYDLAST RLAQKISQIE GVSEVSVGGG
     SLPAVRVALN PDALFNQNVS LDDVRKAISQ SNVRRPQGFI HNDENRWQIQ TNDELSKAQD
     YRPIIVHYNQ DAIVRLSDVA QVTDSVQNAR AAGMSGGEPA ILLVIRREAG ANIIETVNRI
     RDELPELREL LPASVNLKVA QDRTPTIRAS LAEVERALAI AVALVILVVF LFLRSGRATL
     IPAVAVPVSL IGTFSAMYLC GFSLNNLSLM ALTVATGFVV DDAIVVLENI SRHIENGLKP
     KQAALKGVSE VGFTVLSMSI SLVAVFIPLL LMDGLVGRLF KEFAITLTTA IGISLFVSLT
     LTPMMCAHLL KGIKPKAQSH LRGFGKLIFR LQQGYSVTLQ AALRHKRWIM AIFITTLGLN
     AYLYISAPKT FFPDQDTGRL MGFVRADQSI SFQSMKEKMT RFMQEINADK DVDSVTGFTG
     GGRINSGFMF ISLNPLSERT DSANQVINRL RIKLANEPGA TLFLMPVQDV RAGGRQANAS
     YQFTLLADDL SELRKWEPLI RKALGELPEL VDVNSDKEDK GAEMALTYDR DTMSQLGINV
     SDANNLLNNA FGQRQISTIY APLNQYKVVM EVSEQYTQDV SALDKMYVMN TQGERIPLSA
     FASWYPANAP LSVNHQGLSA ASTIAFNVPE GYTLSDAINA IERTMTELGV PNTVRGTFAG
     TAQIFQETIK SQLILILAAI VTVYIVLGVL YESYIHPLTI LSTLPSAGVG ALLALRLFDT
     PFSLIALIGI MLLIGIVKKN AIIMVDFAIT AQREGKLSAQ EAIIQASLLR FRPIIMTTLA
     ALFGALPLML SSGDGAELRQ PLGITIVGGL LMSQLLTLYT TPIIYLFFDG VRQRWQQRRH
     NKKEANA