ID   MDTC_SALCH              Reviewed;        1026 AA.
AC   Q57MM4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE   AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN   Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424}; OrderedLocusNames=SCH_2131;
OS   Salmonella choleraesuis (strain SC-B67).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=321314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC-B67;
RX   PubMed=15781495; DOI=10.1093/nar/gki297;
RA   Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S.,
RA   Lee Y.-S.;
RT   "The genome sequence of Salmonella enterica serovar Choleraesuis, a highly
RT   invasive and resistant zoonotic pathogen.";
RL   Nucleic Acids Res. 33:1690-1698(2005).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
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DR   EMBL; AE017220; AAX66037.1; -; Genomic_DNA.
DR   RefSeq; WP_001540390.1; NC_006905.1.
DR   AlphaFoldDB; Q57MM4; -.
DR   SMR; Q57MM4; -.
DR   EnsemblBacteria; AAX66037; AAX66037; SCH_2131.
DR   KEGG; sec:SCH_2131; -.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; WRGVRTD; -.
DR   Proteomes; UP000000538; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01424; MdtC; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR023931; Multidrug-R_MdtC.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1026
FT                   /note="Multidrug resistance protein MdtC"
FT                   /id="PRO_1000024315"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        528..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        853..873
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        897..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        953..973
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        984..1004
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ   SEQUENCE   1026 AA;  110935 MW;  10E61D441A78A215 CRC64;
     MRFFALFIYR PVATILIAAA ITLCGILGFR LLPVAPLPQV DFPVIMVSAS LPGASPETMA
     SSVATPLERS LGRIAGVNEM TSSSSLGSTR IILEFNFDRD INGAARDVQA AINAAQSLLP
     GGMPSRPTYR KANPSDAPIM ILTLTSESWS QGKLYDFAST QLAQTIAQID GVGDVDVGGS
     SLPAVRVGLN PQALFNQGVS LDEVREAIDS ANVRRPQGAI EDSVHRWQIQ TNDELKTAAE
     YQPLIIHYNN GAAVRLGDVA SVTDSVQDVR NAGMTNAKPA ILLMIRKLPE ANIIQTVDGI
     RAKLPELRAM IPAAIDLQIA QDRSPTIRAS LQEVEETLAI SVALVIMVVF LFLRSGRATL
     IPAVAVPVSL IGTFAAMYLC GFSLNNLSLM ALTIATGFVV DDAIVVLENI ARHLEAGMKP
     LQAALQGTRE VGFTVISMSL SLVAVFLPLL LMGGLPGRLL REFAVTLSVA IGISLVVSLT
     LTPMMCGWML KSSKPRTQPR KRGVGRLLVA LQQGYGTSLK WVLNHTRLVG VVFLGTVALN
     IWLYIAIPKT FFPEQDTGVL MGGIQADQSI SFQAMRGKLQ DFMKIIRDDP AVNNVTGFTG
     GSRVNSGMMF ITLKPRGERK ETAQQIIDRL RVKLAKEPGA RLFLMAVQDI RVGGRQANAS
     YQYTLLSDSL AALREWEPKI RKALSALPQL ADVNSDQQDN GAEMNLIYDR DTMSRLGIDV
     QAANSLLNNA FGQRQISTIY QPMNQYKVVM EVDPRYSQDI SALEKMFVIN RDGKAIPLSY
     FAQWRPANAP LSVNHQGLSA ASTIAFNLPT GTSLSQATEA INRTMTQLGV PPTVRGSFSG
     TAQVFQQTMN SQLILIVAAI ATVYIVLGIL YESYVHPLTI LSTLPSAGVG ALLALELFNA
     PFSLIALIGI MLLIGIVKKN AIMMVDFALE AQRSGGLTPA QAIFQACLLR FRPIMMTTLA
     ALFGALPLVL SGGDGSELRQ PLGITIVGGL VMSQLLTLYT TPVVYLFFDR LRLRFSRKNS
     KPVVEI