ID   MDTC_SALSV              Reviewed;        1026 AA.
AC   B4TNI7;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE   AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN   Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424}; OrderedLocusNames=SeSA_A2365;
OS   Salmonella schwarzengrund (strain CVM19633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=439843;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CVM19633;
RX   PubMed=21602358; DOI=10.1128/jb.00297-11;
RA   Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA   Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT   CRISPR-mediated adaptive sublineage evolution.";
RL   J. Bacteriol. 193:3556-3568(2011).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
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DR   EMBL; CP001127; ACF90568.1; -; Genomic_DNA.
DR   RefSeq; WP_001210092.1; NC_011094.1.
DR   AlphaFoldDB; B4TNI7; -.
DR   SMR; B4TNI7; -.
DR   EnsemblBacteria; ACF90568; ACF90568; SeSA_A2365.
DR   KEGG; sew:SeSA_A2365; -.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; WRGVRTD; -.
DR   Proteomes; UP000001865; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01424; MdtC; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR023931; Multidrug-R_MdtC.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1026
FT                   /note="Multidrug resistance protein MdtC"
FT                   /id="PRO_1000145684"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        528..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        853..873
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        897..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        953..973
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        984..1004
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ   SEQUENCE   1026 AA;  111046 MW;  4FF8F27D3E86A49D CRC64;
     MRFFALFIYR PVATILIAAA ITLCGILGFR LLPVAPLPQV DFPVIMVSAS LPGASPETMA
     SSVATPLERS LGRIAGVNEM TSSSSLGSTR IILEFNFDRD INGAARDVQA AINAAQSLLP
     GGMPSRPTYR KANPSDAPIM ILTLTSESWS QGKLYDFAST QLAQTIAQID GVGDVDVGGS
     SLPAVRVGLN PQALFNQGVS LDEVREAIDS ANVRRPQGAI EDSVHRWQIQ TNDELKTAAE
     YQPLIIHYNN GAAVRLGDVA SVTDSVQDVR NAGMTNAKPA ILLMIRKLPE ANIIQTVDGI
     RAKLPELRAM IPAAIDLQIA QDRSPTIRAS LQEVEETLVI SVALVILVVF LFLRSGRATL
     IPAVAVPVSL IGTFAAMYLC GFSLNNLSLM ALTIATGFVV DDAIVVLENI ARHLEAGMKP
     LQAALQGTRE VGFTVISMSL SLVAVFLPLL LMGGLPGRLL REFAVTLSVA IGISLVVSLT
     LTPMMCGWML KSSKPRTQPR KRGVGRLLVA LQQGYGTSLK WVLNHTRLVG VVFLGTVALN
     IWLYIAIPKT FFPEQDTGVL MGGIQADQSI SFQAMRGKLQ DFMKIIRDDP AVNNVTGFTG
     GSRVNSGMMF ITLKPRGERK ETAQQIIDRL RVKLAKEPGA RLFLMAVQDI RVGGRQANAS
     YQYTLLSDSL AALREWEPKI RKALSALPQL ADVNSDQQDN GAEMNLIYDR DTMSRLGIDV
     QAANSLLNNA FGQRQISTIY QPMNQYKVVM EVDPRYSQDI SALEKMFVIN RDGKAIPLSY
     FAQWRPANAP LSVNHQGLSA ASTIAFNLPT GTSLSQATEA INRTMTQLGV PPTVRGSFSG
     TAQVFQQTMN SQLILIVAAI ATVYIVLGIL YESYVHPLTI LSTLPSAGVG ALLALELFNA
     PFSLIALIGI MLLIGIVKKN AIMMVDFALE AQRSGGLTPE QAIFQACLLR FRPIMMTTLA
     ALFGALPLVL SGGDGSELRQ PLGITIVGGL VMSQLLTLYT TPVVYLFFDR LRRRFSRKNS
     KPVVEI