MDTC_SALTI
ID MDTC_SALTI Reviewed; 1026 AA.
AC Q8Z5F6; Q7CAY7;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN OrderedLocusNames=STY2341, t0744;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC Rule:MF_01424}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01424}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL513382; CAD02491.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO68437.1; -; Genomic_DNA.
DR RefSeq; NP_456674.1; NC_003198.1.
DR RefSeq; WP_001210089.1; NZ_WSUR01000002.1.
DR AlphaFoldDB; Q8Z5F6; -.
DR SMR; Q8Z5F6; -.
DR STRING; 220341.16503355; -.
DR EnsemblBacteria; AAO68437; AAO68437; t0744.
DR KEGG; stt:t0744; -.
DR KEGG; sty:STY2341; -.
DR PATRIC; fig|220341.7.peg.2365; -.
DR eggNOG; COG0841; Bacteria.
DR HOGENOM; CLU_002755_1_2_6; -.
DR OMA; WRGVRTD; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.2090.10; -; 2.
DR HAMAP; MF_01424; MdtC; 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR023931; Multidrug-R_MdtC.
DR PANTHER; PTHR32063; PTHR32063; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82714; SSF82714; 2.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..1026
FT /note="Multidrug resistance protein MdtC"
FT /id="PRO_0000161836"
FT TOPO_DOM 1..6
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 30..335
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..353
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 354..359
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..379
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 380..388
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..411
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 412..430
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..453
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 454..467
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 468..490
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 491..852
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 853..875
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 876..894
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 895..917
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 918..947
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 948..970
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 971..984
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 985..1007
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 1008..1026
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1026 AA; 111049 MW; 21653DA424C668FF CRC64;
MRFFALFIYR PVATILIAAA ITLCGILGFR LLPVAPLPQV DFPVIMVSAS LPGASPETMA
SSVATPLERS LGRIAGVNEM TSSSSLGSTR IILEFNFDRD INGAARDVQA AINAAQSLLP
GGMPSRPTYR KANPSDAPIM ILTLTSESWS QGKLYDFAST QLAQTIAQID GVGDVDVGGS
SLPAVRVGLN PQALFNQGVS LDEVREAIDS ANVRRPQGAI EDSVHRWQIQ TNDELKTAAE
YQPLIIHYNN GAAVRLGDVA SVTDSVQDVR NAGMTNAKPA ILLMIRKLPE ANIIQTVDGI
RAKLPELRAM IPAAIDLQIA QDRSPTIRAS LQEVEETLAI SVALVILVVF LFLRSGRATL
IPAVAVPVSL IGTFAAMYLC GFSLNNLSLM ALTIATGFVV DDAIVVLENI ARHLEARMKP
LQAALQGTRE VGFTVISMSL SLVAVFLPLL LMGGLPGRLL REFAVTLSVA IGISLVVSLT
LTPMMCGWML KSSKPRTQPR KRGVGRLLVA LQQGYGTSLK WVLNHTRLVG VVFLGTVALN
IWLYIAIPKT FFPEQDTGVL MGGIQADQSI SFQAMRGKLQ DFMKIIRDDP AVNNVTGFTG
GSRVNSGMMF ITLKPRGERK ETAQQVIDRL RVKLAKEPGA KLFLMAVQDI RVGGRQANAS
YQYTLLSDSL PALREWEPKI RKALSALPQL ADVNSDQQDN GAEMNLIYDR DTMSRLGIDV
QAANSLLNNA FGQRQISTIY QPMNQYKVVM EVDPRYSQDI SALEKMFVIN RDGKAIPLSY
FAQWRPANAP LSVNHQGLSA ASTIAFNLPT GTSLSQATEA IDRTMTQLGV PSTVRGSFSG
TAQVFQQTMN SQLILIVAAI ATVYIVLGIL YESYVHPLTI LSTLPSAGVG ALLALELFNA
PFSLIALIGI MLLIGIVKKN AIMMVDFALE AQRSGGLTPE QAIFQACLLR FRPIMMTTLA
ALFGALPLVL SGGDGSELRQ PLGITIVGGL VMSQLLTLYT TPVVYLFFDR LRLRFSRKNS
KPVVEI
