ID   MDTC_SERP5              Reviewed;        1026 AA.
AC   A8GHR0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE   AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN   Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424}; OrderedLocusNames=Spro_3554;
OS   Serratia proteamaculans (strain 568).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=399741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=568;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L.,
RA   Vangronsveld J., van der Lelie D., Richardson P.;
RT   "Complete sequence of chromosome of Serratia proteamaculans 568.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000826; ABV42650.1; -; Genomic_DNA.
DR   RefSeq; WP_012146263.1; NC_009832.1.
DR   AlphaFoldDB; A8GHR0; -.
DR   SMR; A8GHR0; -.
DR   STRING; 399741.Spro_3554; -.
DR   EnsemblBacteria; ABV42650; ABV42650; Spro_3554.
DR   KEGG; spe:Spro_3554; -.
DR   eggNOG; COG0841; Bacteria.
DR   HOGENOM; CLU_002755_1_2_6; -.
DR   OMA; WRGVRTD; -.
DR   OrthoDB; 145346at2; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01424; MdtC; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR023931; Multidrug-R_MdtC.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1026
FT                   /note="Multidrug resistance protein MdtC"
FT                   /id="PRO_1000068509"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        528..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        853..873
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        897..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        953..973
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        984..1004
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ   SEQUENCE   1026 AA;  110882 MW;  C74001486ED8A216 CRC64;
     MKFFALFIYR PVATTLLTLA IAISGVISFS LLPVSPLPQV DYPVISISAS LPGADPETMA
     SSVATPLERA LGRIAGVNEM TSMSSLGSTR VILQFDLDRD INGAARDVQA AINAAQSLLP
     TGMPSRPSYR KVNPSDAPIM ILTLTSDTYS QGQLYDFAST QLAQKIAQTE GVGDVSVGGS
     SLPAVRVELN PSALFNQGIS LDAVRQTISN ANVRRPQGSV ENQQQRWQIQ ANDELKTAEV
     YRPLIIHYNN GSAVRLSDVA EVNDSVQDVR NAGMTNAKPA IILTISRAPD ANIIETVDRI
     RAELPTLQNN IPASIQLNIA QDRSPTIRAS LAEVEQSLVI AIGLVILVVF IFLRSGRATL
     IPAVAVPVSL IGSFTAMYLC GFSLNNLSLM ALTIATGFVV DDAIVVLENI SRHIEAGMKP
     INAALVGVRE VGFTVLSMSV SLVAVFIPLL LMEGLPGRLF REFAVTLSVS IGLSLIISLT
     LTPMMCAYLL RHQPPRSQRR IRGFGKMLLA LQKGYGRSLS WVLGHSRWVL AVFLATIALN
     VWLYVSIPKT FFPEQDTGRL MGFIQADQSI SFQAMRVKLE DFMKIVREDP DVDNVTGFTG
     GSRTNSGSMF ISLKPLSVRS DDAQKVIARL RAKLAKEPGA SLFLMAVQDI RVGGRQANAS
     YQYTLMADDL AALREWEPKI RTALAALPEL ADVNSDQQDK GSEMDLVYDR ETMARLGISV
     SDANNLLNNA FGQRQISTIY QPLNQYKVVM EVAPPYTQDV SSLDKMFVIN SDGKAIPLSY
     FASWRPANAP LSVNHQGLSA ASTISFNLPD GGSLSDATAG IERTMTALGV PATVRGAFAG
     TAQVFQETLK SQLLLIAAAI ATVYIVLGIL YESYIHPLTI LSTLPSAGVG ALLALELFGA
     PFSLIALIGI MLLIGIVKKN AIMMVDFALD AQRNGGISAH DAIFQACLLR FRPIMMTTLA
     ALFGALPLVL THGDGAELRQ PLGITIVGGL IVSQLLTLYT TPVVYLYFDR LQMKFRRGKK
     LDPLPQ