MDTC_SHIFL
ID MDTC_SHIFL Reviewed; 1021 AA.
AC Q83KI4; Q7UCB2;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN OrderedLocusNames=SF2141, S2266;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC Rule:MF_01424}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01424}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
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DR EMBL; AE005674; AAN43675.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP17501.1; -; Genomic_DNA.
DR RefSeq; NP_707968.1; NC_004337.2.
DR AlphaFoldDB; Q83KI4; -.
DR SMR; Q83KI4; -.
DR STRING; 198214.SF2141; -.
DR EnsemblBacteria; AAN43675; AAN43675; SF2141.
DR EnsemblBacteria; AAP17501; AAP17501; S2266.
DR GeneID; 1025329; -.
DR KEGG; sfl:SF2141; -.
DR KEGG; sfx:S2266; -.
DR PATRIC; fig|198214.7.peg.2556; -.
DR HOGENOM; CLU_002755_1_2_6; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.2090.10; -; 2.
DR HAMAP; MF_01424; MdtC; 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR023931; Multidrug-R_MdtC.
DR PANTHER; PTHR32063; PTHR32063; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82714; SSF82714; 2.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1021
FT /note="Multidrug resistance protein MdtC"
FT /id="PRO_0000161838"
FT TOPO_DOM 1..6
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 30..335
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 336..353
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 354..359
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..379
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 380..388
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..411
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 412..430
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..453
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 454..467
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 468..490
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 491..848
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 849..871
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 872..890
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 891..913
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 914..943
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 944..966
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 967..980
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 981..1003
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TOPO_DOM 1004..1021
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 601
FT /note="S -> N (in Ref. 2; AAP17501)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1021 AA; 110483 MW; 7E9AFDCBEF94F139 CRC64;
MKFFALFIYR PVATILLSVA ITLCGILGFR MLPVAPLPQV DFPVIMVSAS LPGASPETMA
SSVATPLERS LGRIAGVSEM TSSSSLGSTR IILQFDFDRD INGAARDVQA AINAAQSLLP
SGMPSRPTYR KANPSDAPIM ILTLTSDTYS QGELYDFAST QLAPTISQID GVGDVDVGGS
SLPAVRVGLT PQALFNQGVS LDDVRTAISN ANVRKPQGAL EDGTHRWQIQ TNDELKTAAE
YQPLIIHYNN GGAVRLGDVA TVTDSVQDVR NAGMTNAKPA ILLMIRKLPE ANIIQTVDSI
RAKLPELQET IPAAIDLQIA QDRSPTIRAS LEEVEQTLII SVALVILVVF LFLRSGRATI
IPAVAVPVSL IGTFAAMYLC GFSLNNLSLM ALTIATGFVV DDAIVVLENI ARHLEAGMKP
LQAALQGTRE VGFTVLSMSL SLVAVFLPLL LMGGLPGRLL REFAVTLSVA IGISLLVSLT
LTPMMCGWML KASKPREQKR LRGFGRMLVA LQQGYGKSLK WVLNHTRLVG VVLLGTIALN
ISIPKTFFPE QDTGVLMGGI QADQSISFQA MRGKLQDFMK IIRDDPAVDN VTGFTGGSRV
SSGMMFITLK PRDERSETAQ QIIDRLRVKL AKEPGANLFL MAVQDIRVGG RQSNASYQYT
LLSDDLAALR EWEPKIRKKL ATLPELADVN SDQQDNGAEM NLVYDRDTMA RLGIDVQAAN
SLLNNAFGQR QISTIYQPMN QYKVVMEVDP RYTQDISALE KMFVINNEGK AIPLSYFAKW
QPANAPLSVN HQGLSAASTI SFNLPTGKSL SDASAAIDRA MTQLGVPSTV RGSFAGTAQV
FQETMNSQVI LIIAAIATVY IVLGILYESY VHPLTILSTL PSAGVGALLA LELFNAPFSL
IALIGIMLLI GIVKKNAIMM VDFALEAQRH GNLTPQEAIF QACLLRFRPI MMTTLAALFG
ALPLVLSGGD GSELRQPLEI TIVGGLVMSQ LLTLYTTPVV YLFFDRLRLR FSRKPKQTVT
E
