MDTC_XENBS
ID MDTC_XENBS Reviewed; 1027 AA.
AC D3V7P4;
DT 16-NOV-2011, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 25-MAY-2022, entry version 61.
DE RecName: Full=Multidrug resistance protein MdtC;
DE AltName: Full=Multidrug transporter MdtC;
GN Name=mdtC; OrderedLocusNames=XBJ1_2732;
OS Xenorhabdus bovienii (strain SS-2004).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Xenorhabdus.
OX NCBI_TaxID=406818;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SS-2004;
RX PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C., de Leon L.,
RA Drace K., Du Z., Givaudan A., Herbert Tran E.E., Jewell K.A., Knack J.J.,
RA Krasomil-Osterfeld K.C., Kukor R., Lanois A., Latreille P.,
RA Leimgruber N.K., Lipke C.M., Liu R., Lu X., Martens E.C., Marri P.R.,
RA Medigue C., Menard M.L., Miller N.M., Morales-Soto N., Norton S.,
RA Ogier J.C., Orchard S.S., Park D., Park Y., Qurollo B.A., Sugar D.R.,
RA Richards G.R., Rouy Z., Slominski B., Slominski K., Snyder H., Tjaden B.C.,
RA van der Hoeven R., Welch R.D., Wheeler C., Xiang B., Barbazuk B.,
RA Gaudriault S., Goodner B., Slater S.C., Forst S., Goldman B.S.,
RA Goodrich-Blair H.;
RT "The entomopathogenic bacterial endosymbionts xenorhabdus and photorhabdus:
RT convergent lifestyles from divergent genomes.";
RL PLoS ONE 6:E27909-E27909(2011).
CC -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC MdtC. MdtC forms a heteromultimer with MdtB (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MdtC subfamily. {ECO:0000305}.
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DR EMBL; FN667741; CBJ81856.1; -; Genomic_DNA.
DR RefSeq; WP_012989142.1; NC_013892.1.
DR AlphaFoldDB; D3V7P4; -.
DR SMR; D3V7P4; -.
DR STRING; 406818.XBJ1_2732; -.
DR PRIDE; D3V7P4; -.
DR EnsemblBacteria; CBJ81856; CBJ81856; XBJ1_2732.
DR GeneID; 8832348; -.
DR KEGG; xbo:XBJ1_2732; -.
DR PATRIC; fig|406818.4.peg.2466; -.
DR eggNOG; COG0841; Bacteria.
DR HOGENOM; CLU_002755_1_2_6; -.
DR OMA; WRGVRTD; -.
DR Proteomes; UP000002045; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.2090.10; -; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR PANTHER; PTHR32063; PTHR32063; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82714; SSF82714; 2.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1027
FT /note="Multidrug resistance protein MdtC"
FT /id="PRO_0000414037"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 432..452
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 463..483
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 851..871
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 873..893
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 895..915
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 951..971
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 982..1002
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1027 AA; 111913 MW; 9C561CDCCAC62C5A CRC64;
MKFFALFIQR PVATTLLSLA ITLCGALSFI LLPVSPLPKM DYPFISVSAY MPGASPETMA
SSVATPLERS LGKIAGVKEM SSNSSLGNTN ITLEFELSRD INGAARDVQA AINAAESLLP
SGMPSRPRYY KANLSDSPIM ILTLTSTNHS VGQLYDIAST YLAQKLSQVE GVSNVSVGGG
SLPAVRIELN PNALFNQGVS LNDVSQAINS ANAQRPTGHV DSAQQNWQVH TNDELKNADS
YRSIIVHYRN GSPVRLQDVA NIKDSVENTR VAGMSGGEPA IVLVIRRESG ANIIATIDRI
RAELPVLRES IPANIQFNIA QERSPTIRAS LQEVKQSLAI AVALVILVVF LFLRSGRATL
IPAIAVPVSL IGTFTAMYLC GFSLNNLSLM ALTIATGFVV DDAIVVLENI SRHLEAGLKP
AQAALKGVRE VGFTVLAMSV SLVAVFIPLV LIDELLGRMF RDFAVTLATA IGISLLISLT
LTPMMCAHLL KSSPQKSQKR IRGFSKVLLK IQQGYGRSLK WVLNHTRWVL LTLIGIVVLN
VWLYINIPKT LFPQQDTGRI LGFVIADENS SFQSMRDKMK HFMQVINADP TVENVEGFTE
SSSGFMFIAL KPLKERTESI EKVIIRLKGK LSNEAGAQLY LLPIQELKLG GRGGAKSIYQ
FALLSDDLGE LRKWEPIIRK ALAKLPQLTD VNSDYENKGS EIAIIYDRDL MARLGISVNE
ANALLSNAFG QQSISTIYLP RNQYKVVMEV APEYTQDASS LEKMFVINAK GERIPLSYFA
RWQPANAPSG VYHQGLSASS TIAFNVAENY TLSDAISAIE RTMTELSVPS AVRSSFAGIA
QDFQKTQSSQ LWVILAAIVT VYLVLGVLYE SYIHPLTILS TLPSAGVGAL LALELFNTPF
SLIAMVGIML LIGIVKKNAI IMVDFALEAQ KSGKLSAQEA ILQASLLRFR PIMMTTLSAL
FGALPLVLNS GDGAELRQPL GITIVGGLVM SQLLTLYTTP VVYLFFDRLR KKWHHRRTIK
SQVVKSS
