MDTC_YERE8
ID MDTC_YERE8 Reviewed; 1024 AA.
AC A1JKW9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424}; OrderedLocusNames=YE1107;
OS Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS 8081).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=393305;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 13174 / 8081;
RX PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA Prentice M.B.;
RT "The complete genome sequence and comparative genome analysis of the high
RT pathogenicity Yersinia enterocolitica strain 8081.";
RL PLoS Genet. 2:2039-2051(2006).
CC -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC Rule:MF_01424}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01424}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
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DR EMBL; AM286415; CAL11203.1; -; Genomic_DNA.
DR RefSeq; WP_011815800.1; NC_008800.1.
DR RefSeq; YP_001005437.1; NC_008800.1.
DR AlphaFoldDB; A1JKW9; -.
DR SMR; A1JKW9; -.
DR STRING; 393305.YE1107; -.
DR EnsemblBacteria; CAL11203; CAL11203; YE1107.
DR KEGG; yen:YE1107; -.
DR PATRIC; fig|393305.7.peg.1208; -.
DR eggNOG; COG0841; Bacteria.
DR HOGENOM; CLU_002755_1_2_6; -.
DR OMA; WRGVRTD; -.
DR Proteomes; UP000000642; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.2090.10; -; 2.
DR HAMAP; MF_01424; MdtC; 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR023931; Multidrug-R_MdtC.
DR PANTHER; PTHR32063; PTHR32063; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82714; SSF82714; 2.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..1024
FT /note="Multidrug resistance protein MdtC"
FT /id="PRO_1000024320"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 463..483
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 853..873
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 875..895
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 897..917
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 953..973
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 984..1004
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ SEQUENCE 1024 AA; 110579 MW; 4ABD43D2E7F59F81 CRC64;
MKFFALFIQR PVATTLLTLA ITLSGVIGFS LLPVSPLPQV DYPVIMVSAS MPGADPETMA
SSIATPLERA LGRIAGVNEM TSTSSLGSTR IILQFDLSRD INGAARDVQA ALNAAQSLLP
SGMPNRPTYR KMNPSDAPIM IMTLTSDTFS QGQLYDFAST QLAQKIAQTE GVSDVSVGGS
SLPAVRVELN PSALFNQGVS LDAVRQAISA ANVRRPQGSI DSSEQHWQVQ ANDEIKTAEG
YRPLIIHYNN GSPVRLQDVA NIVDSVQDVR NAGMSDGKPA VLLVISREPG ANIIATVDRI
RAELPALRAS IPASIELNIA QDRSPTIRAS LDEVERSLVI AVALVILVVF LFLRSGRATL
IPAVAVPVSL IGTFTAMYLC GFSLNNLSLM ALTIATGFVV DDAIVVLENI SRHLEAGVKP
MVAALRGVRE VGFTVLSMSI SLVAVFIPLL LMEGLPGRLF REFAVTLSVA IGISLVISLT
LTPMMCAHLL RAQPTGKQQR IRGFGKVLLA IQQGYGRSLN WVLGHTRWVM VVLLSTIALN
VWLYISIPKT FFPEQDTGRM MGFIQADQSI SFQAMQQKLK DFMKIVSADP AVDNVTGFTG
GSRTNSGSMF ISLKPLSERS ETAQQVITRL RGKLAKEPGA SLFLSPVQDI RVGGRQSNAS
YQFTLLADDL AALREWEPKV RAALSKLPEL ADVNSDQQDK GSEMALTYDR ETMARLGIDV
SDANALLNNA FGQRQISTIY QPLNQYKVVM EVAPQYTQDV SSLDKMFVIN SNGQSIPLSY
FAKWQPANAP LSVNHQGLSA ASTISFNLPD GGSLSEATAA VERAMTELGV PSTVRGMFAG
TAQVFQDTLK SQLWLIMAAI ATVYIVLGIL YESYVHPLTI LSTLPSAGVG ALLALELFDA
PFSLIALIGI MLLIGIVKKN AIMMVDFALD AQRNGNLNAR DAIFQASLLR FRPILMTTLA
ALFGALPLVI SSGDGAELRQ PLGITIVGGL VMSQLLTLYT TPVVYLYFDR LRSRFSKKPL
MRLE
