ID   MDTC_YERPA              Reviewed;        1024 AA.
AC   Q1C5L9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE   AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN   Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424}; OrderedLocusNames=YPA_2288;
OS   Yersinia pestis bv. Antiqua (strain Antiqua).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=360102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Antiqua;
RX   PubMed=16740952; DOI=10.1128/jb.00124-06;
RA   Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M.,
RA   Worsham P., Chu M.C., Andersen G.L.;
RT   "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516:
RT   evidence of gene reduction in an emerging pathogen.";
RL   J. Bacteriol. 188:4453-4463(2006).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
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DR   EMBL; CP000308; ABG14253.1; -; Genomic_DNA.
DR   RefSeq; WP_002209794.1; NZ_CP009906.1.
DR   AlphaFoldDB; Q1C5L9; -.
DR   SMR; Q1C5L9; -.
DR   EnsemblBacteria; ABG14253; ABG14253; YPA_2288.
DR   GeneID; 57975807; -.
DR   KEGG; ypa:YPA_2288; -.
DR   OMA; WRGVRTD; -.
DR   Proteomes; UP000001971; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01424; MdtC; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR023931; Multidrug-R_MdtC.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1024
FT                   /note="Multidrug resistance protein MdtC"
FT                   /id="PRO_1000024321"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        435..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        469..489
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        528..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        853..873
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        875..895
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        897..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        953..973
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        984..1004
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ   SEQUENCE   1024 AA;  110386 MW;  CFA7627F2222F5FA CRC64;
     MKFFALFIQR PVATTLLTLA ITLSGIIGFS LLPVSPLPQV DYPVIMVSAS MPGADPETMA
     SSVATPLERA LGRIAGVNEM TSTSSLGSTR IILQFDLNRD INGAARDVQA ALNAAQSLLP
     SGMPSRPTYR KMNPSDAPIM IMTLTSDTFS QGQLYDYAST KLAQKIAQTE GVSDVTVGGS
     SLPAVRVELN PSALFNQGVS LDAVRQAISA ANVRRPQGSV DAAETHWQVQ ANDEIKTAEG
     YRPLIVHYNN GSPVRLQDVA NVIDSVQDVR NAGMSAGQPA VLLVISREPG ANIIATVDRI
     RAELPALRAS IPASIQLNIA QDRSPTIRAS LDEVERSLVI AVALVILVVF IFLRSGRATL
     IPAVAVPVSL IGTFAAMYLC GFSLNNLSLM ALTIATGFVV DDAIVVLENI SRHLEAGVKP
     KVAALRGVRE VGFTVLSMSI SLVAVFIPLL LMAGLPGRLF REFAVTLSVA IGISLVISLT
     LTPMMCAWLL RSHPKGQQQR IRGFGKVLLA IQQGYGRSLN WALSHTRWVM VVLLSTIALN
     VWLYISIPKT FFPEQDTGRM MGFIQADQSI SFQSMQQKLK DFMQIVGADP AVDSVTGFTG
     GSRTNSGSMF ISLKPLSERQ ETAQQVITRL RGKLAKEPGA NLFLSSVQDI RVGGRHSNAA
     YQFTLLADDL AALREWEPKV RAALAKLPQL ADVNSDQQDK GAEMALTYDR ETMARLGIDV
     SEANALLNNA FGQRQISTIY QPLNQYKVVM EVAPEYTQDV SSLDKMFVIN SNGQSIPLSY
     FAKWQPANAP LAVNHQGLSA ASTISFNLPD GGSLSEATAA VERAMTELGV PSTVRGAFAG
     TAQVFQETLK SQLWLIMAAI ATVYIVLGIL YESYVHPLTI LSTLPSAGVG ALLALELFDA
     PFSLIALIGI MLLIGIVKKN AIMMVDFALD AQRNGNISAR EAIFQASLLR FRPIIMTTLA
     ALFGALPLVL SSGDGAELRQ PLGITIVGGL VVSQLLTLYT TPVIYLYFDR LRNRFSKQPL
     MKLE