MDTC_YERPE
ID MDTC_YERPE Reviewed; 1024 AA.
AC Q8ZCV9; Q0WD51; Q74SA6; Q7CJL0;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN OrderedLocusNames=YPO2849, y1384, YP_2716;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC Rule:MF_01424}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01424}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
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DR EMBL; AL590842; CAL21461.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM84956.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS62905.1; -; Genomic_DNA.
DR PIR; AB0347; AB0347.
DR RefSeq; WP_002209794.1; NZ_WHLN01000041.1.
DR RefSeq; YP_002347787.1; NC_003143.1.
DR AlphaFoldDB; Q8ZCV9; -.
DR SMR; Q8ZCV9; -.
DR IntAct; Q8ZCV9; 4.
DR STRING; 214092.YPO2849; -.
DR PaxDb; Q8ZCV9; -.
DR DNASU; 1146331; -.
DR EnsemblBacteria; AAM84956; AAM84956; y1384.
DR EnsemblBacteria; AAS62905; AAS62905; YP_2716.
DR GeneID; 57975807; -.
DR KEGG; ype:YPO2849; -.
DR KEGG; ypk:y1384; -.
DR KEGG; ypm:YP_2716; -.
DR PATRIC; fig|1028802.3.peg.1514; -.
DR eggNOG; COG0841; Bacteria.
DR HOGENOM; CLU_002755_1_2_6; -.
DR OMA; WRGVRTD; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 3.30.2090.10; -; 2.
DR HAMAP; MF_01424; MdtC; 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR023931; Multidrug-R_MdtC.
DR PANTHER; PTHR32063; PTHR32063; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82714; SSF82714; 2.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1024
FT /note="Multidrug resistance protein MdtC"
FT /id="PRO_0000161839"
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 336..353
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 360..379
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 389..411
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 431..453
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 468..490
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 853..875
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 895..917
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 948..970
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 985..1007
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ SEQUENCE 1024 AA; 110386 MW; CFA7627F2222F5FA CRC64;
MKFFALFIQR PVATTLLTLA ITLSGIIGFS LLPVSPLPQV DYPVIMVSAS MPGADPETMA
SSVATPLERA LGRIAGVNEM TSTSSLGSTR IILQFDLNRD INGAARDVQA ALNAAQSLLP
SGMPSRPTYR KMNPSDAPIM IMTLTSDTFS QGQLYDYAST KLAQKIAQTE GVSDVTVGGS
SLPAVRVELN PSALFNQGVS LDAVRQAISA ANVRRPQGSV DAAETHWQVQ ANDEIKTAEG
YRPLIVHYNN GSPVRLQDVA NVIDSVQDVR NAGMSAGQPA VLLVISREPG ANIIATVDRI
RAELPALRAS IPASIQLNIA QDRSPTIRAS LDEVERSLVI AVALVILVVF IFLRSGRATL
IPAVAVPVSL IGTFAAMYLC GFSLNNLSLM ALTIATGFVV DDAIVVLENI SRHLEAGVKP
KVAALRGVRE VGFTVLSMSI SLVAVFIPLL LMAGLPGRLF REFAVTLSVA IGISLVISLT
LTPMMCAWLL RSHPKGQQQR IRGFGKVLLA IQQGYGRSLN WALSHTRWVM VVLLSTIALN
VWLYISIPKT FFPEQDTGRM MGFIQADQSI SFQSMQQKLK DFMQIVGADP AVDSVTGFTG
GSRTNSGSMF ISLKPLSERQ ETAQQVITRL RGKLAKEPGA NLFLSSVQDI RVGGRHSNAA
YQFTLLADDL AALREWEPKV RAALAKLPQL ADVNSDQQDK GAEMALTYDR ETMARLGIDV
SEANALLNNA FGQRQISTIY QPLNQYKVVM EVAPEYTQDV SSLDKMFVIN SNGQSIPLSY
FAKWQPANAP LAVNHQGLSA ASTISFNLPD GGSLSEATAA VERAMTELGV PSTVRGAFAG
TAQVFQETLK SQLWLIMAAI ATVYIVLGIL YESYVHPLTI LSTLPSAGVG ALLALELFDA
PFSLIALIGI MLLIGIVKKN AIMMVDFALD AQRNGNISAR EAIFQASLLR FRPIIMTTLA
ALFGALPLVL SSGDGAELRQ PLGITIVGGL VVSQLLTLYT TPVIYLYFDR LRNRFSKQPL
MKLE
