MDTC_YERPN
ID MDTC_YERPN Reviewed; 1024 AA.
AC Q1CK61; C4GRP3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424}; OrderedLocusNames=YPN_1289;
GN ORFNames=YP516_1419;
OS Yersinia pestis bv. Antiqua (strain Nepal516).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=377628;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nepal516;
RX PubMed=16740952; DOI=10.1128/jb.00124-06;
RA Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M.,
RA Worsham P., Chu M.C., Andersen G.L.;
RT "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516:
RT evidence of gene reduction in an emerging pathogen.";
RL J. Bacteriol. 188:4453-4463(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nepal516;
RA Plunkett G. III, Anderson B.D., Baumler D.J., Burland V., Cabot E.L.,
RA Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R.,
RA Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S.;
RT "Yersinia pestis Nepal516A whole genome shotgun sequencing project.";
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC Rule:MF_01424}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01424}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
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DR EMBL; CP000305; ABG17619.1; -; Genomic_DNA.
DR EMBL; ACNQ01000008; EEO77734.1; -; Genomic_DNA.
DR RefSeq; WP_002209794.1; NZ_ACNQ01000008.1.
DR AlphaFoldDB; Q1CK61; -.
DR SMR; Q1CK61; -.
DR EnsemblBacteria; ABG17619; ABG17619; YPN_1289.
DR GeneID; 57975807; -.
DR KEGG; ypn:YPN_1289; -.
DR HOGENOM; CLU_002755_1_2_6; -.
DR OMA; WRGVRTD; -.
DR Proteomes; UP000008936; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.2090.10; -; 2.
DR HAMAP; MF_01424; MdtC; 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR023931; Multidrug-R_MdtC.
DR PANTHER; PTHR32063; PTHR32063; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82714; SSF82714; 2.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..1024
FT /note="Multidrug resistance protein MdtC"
FT /id="PRO_1000024322"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 435..455
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 469..489
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 853..873
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 875..895
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 897..917
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 953..973
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT TRANSMEM 984..1004
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ SEQUENCE 1024 AA; 110386 MW; CFA7627F2222F5FA CRC64;
MKFFALFIQR PVATTLLTLA ITLSGIIGFS LLPVSPLPQV DYPVIMVSAS MPGADPETMA
SSVATPLERA LGRIAGVNEM TSTSSLGSTR IILQFDLNRD INGAARDVQA ALNAAQSLLP
SGMPSRPTYR KMNPSDAPIM IMTLTSDTFS QGQLYDYAST KLAQKIAQTE GVSDVTVGGS
SLPAVRVELN PSALFNQGVS LDAVRQAISA ANVRRPQGSV DAAETHWQVQ ANDEIKTAEG
YRPLIVHYNN GSPVRLQDVA NVIDSVQDVR NAGMSAGQPA VLLVISREPG ANIIATVDRI
RAELPALRAS IPASIQLNIA QDRSPTIRAS LDEVERSLVI AVALVILVVF IFLRSGRATL
IPAVAVPVSL IGTFAAMYLC GFSLNNLSLM ALTIATGFVV DDAIVVLENI SRHLEAGVKP
KVAALRGVRE VGFTVLSMSI SLVAVFIPLL LMAGLPGRLF REFAVTLSVA IGISLVISLT
LTPMMCAWLL RSHPKGQQQR IRGFGKVLLA IQQGYGRSLN WALSHTRWVM VVLLSTIALN
VWLYISIPKT FFPEQDTGRM MGFIQADQSI SFQSMQQKLK DFMQIVGADP AVDSVTGFTG
GSRTNSGSMF ISLKPLSERQ ETAQQVITRL RGKLAKEPGA NLFLSSVQDI RVGGRHSNAA
YQFTLLADDL AALREWEPKV RAALAKLPQL ADVNSDQQDK GAEMALTYDR ETMARLGIDV
SEANALLNNA FGQRQISTIY QPLNQYKVVM EVAPEYTQDV SSLDKMFVIN SNGQSIPLSY
FAKWQPANAP LAVNHQGLSA ASTISFNLPD GGSLSEATAA VERAMTELGV PSTVRGAFAG
TAQVFQETLK SQLWLIMAAI ATVYIVLGIL YESYVHPLTI LSTLPSAGVG ALLALELFDA
PFSLIALIGI MLLIGIVKKN AIMMVDFALD AQRNGNISAR EAIFQASLLR FRPIIMTTLA
ALFGALPLVL SSGDGAELRQ PLGITIVGGL VVSQLLTLYT TPVIYLYFDR LRNRFSKQPL
MKLE
