ID   MDTC_YERPS              Reviewed;        1024 AA.
AC   Q668C5;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Multidrug resistance protein MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
DE   AltName: Full=Multidrug transporter MdtC {ECO:0000255|HAMAP-Rule:MF_01424};
GN   Name=mdtC {ECO:0000255|HAMAP-Rule:MF_01424}; OrderedLocusNames=YPTB2815;
OS   Yersinia pseudotuberculosis serotype I (strain IP32953).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=273123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP32953;
RX   PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA   Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA   Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA   Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA   Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA   Derbise A., Hauser L.J., Garcia E.;
RT   "Insights into the evolution of Yersinia pestis through whole-genome
RT   comparison with Yersinia pseudotuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC   -!- SUBUNIT: Part of a tripartite efflux system composed of MdtA, MdtB and
CC       MdtC. MdtC forms a heteromultimer with MdtB. {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01424}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01424}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MdtC subfamily. {ECO:0000255|HAMAP-Rule:MF_01424}.
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DR   EMBL; BX936398; CAH22053.1; -; Genomic_DNA.
DR   RefSeq; WP_011192783.1; NZ_CP009712.1.
DR   AlphaFoldDB; Q668C5; -.
DR   SMR; Q668C5; -.
DR   EnsemblBacteria; CAH22053; CAH22053; YPTB2815.
DR   GeneID; 66844762; -.
DR   KEGG; ypo:BZ17_3816; -.
DR   KEGG; yps:YPTB2815; -.
DR   PATRIC; fig|273123.14.peg.4005; -.
DR   OMA; WRGVRTD; -.
DR   Proteomes; UP000001011; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   HAMAP; MF_01424; MdtC; 1.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR023931; Multidrug-R_MdtC.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1024
FT                   /note="Multidrug resistance protein MdtC"
FT                   /id="PRO_0000161840"
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        336..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        360..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        389..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        431..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        468..490
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        853..875
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        895..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        948..970
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
FT   TRANSMEM        985..1007
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01424"
SQ   SEQUENCE   1024 AA;  110359 MW;  23BB1C7D8D39AFC3 CRC64;
     MKFFALFIQR PVATTLLTLA ITLSGIIGFS LLPVSPLPQV DYPVIMVSAS MPGADPETMA
     SSVATPLERA LGRIAGVNEM TSTSSLGSTR IILQFDLNRD INGAARDVQA ALNAAQSLLP
     SGMPSRPTYR KMNPSDAPIM IMTLTSDTFS QGQLYDYAST KLAQKIAQTE GVSDVTVGGS
     SLPAVRVELN PSALFNQGVS LDAVRQAISA ANVRRPQGSV DAAETHWQVQ ANDEIKTAEG
     YRPLIVHYNN GSPVRLQDVA NVIDSVQDVR NAGMSAGQPA VLLVISREPG ANIIATVDRI
     RAELPALRAS IPASIQLNIA QDRSPTIRAS LDEVERSLVI AVALVILVVF IFLRSGRATL
     IPAVAVPVSL IGTFAAMYLC GFSLNNLSLM ALTIATGFVV DDAIVVLENI SRHLEAGVKP
     MVAALRGVRE VGFTVLSMSI SLVAVFIPLL LMAGLPGRLF REFAVTLSVA IGISLVISLT
     LTPMMCAWLL RSHPKGQQQR IRGFGKVLLA IQQGYGRSLN WALGHTRWVM VVLLSTIALN
     VWLYISIPKT FFPEQDTGRM MGFIQADQSI SFQSMQQKLK DFMQIVGADP AVDSVTGFTG
     GSRTNSGSMF ISLKPLSERQ ETAQQVITRL RGKLAKEPGA NLFLSSVQDI RVGGRHSNAA
     YQFTLLADDL AALREWEPKV RAALAKLPQL ADVNSDQQDK GAEMALTYDR ETMARLGIDV
     SEANALLNNA FGQRQISTIY QPLNQYKVVM EVAPEYTQDV SSLDKMFVIN SNGQSIPLSY
     FAKWQPANAP LAVNHQGLSA ASTISFNLPD GGSLSEATAA VERAMTELGV PSTVRGAFAG
     TAQVFQETLK SQLWLIMAAI ATVYIVLGIL YESYVHPLTI LSTLPSAGVG ALLALELFDA
     PFSLIALIGI MLLIGIVKKN AIMMVDFALD AQRNGNISAR EAIFQASLLR FRPIIMTTLA
     ALFGALPLVL SSGDGAELRQ PLGITIVGGL VVSQLLTLYT TPVIYLYFDR LRNRFSKQPL
     MKLE