ID   MDTD_CITK8              Reviewed;         471 AA.
AC   A8AEE4;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Putative multidrug resistance protein MdtD {ECO:0000255|HAMAP-Rule:MF_01577};
GN   Name=mdtD {ECO:0000255|HAMAP-Rule:MF_01577}; OrderedLocusNames=CKO_00704;
OS   Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Citrobacter.
OX   NCBI_TaxID=290338;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-895 / CDC 4225-83 / SGSC4696;
RG   The Citrobacter koseri Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA   Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W.,
RA   Johnson M., Thiruvilangam P., Wilson R.;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01577}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01577}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000255|HAMAP-Rule:MF_01577}.
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DR   EMBL; CP000822; ABV11857.1; -; Genomic_DNA.
DR   RefSeq; WP_012131681.1; NC_009792.1.
DR   AlphaFoldDB; A8AEE4; -.
DR   SMR; A8AEE4; -.
DR   STRING; 290338.CKO_00704; -.
DR   EnsemblBacteria; ABV11857; ABV11857; CKO_00704.
DR   GeneID; 45134920; -.
DR   KEGG; cko:CKO_00704; -.
DR   HOGENOM; CLU_000960_28_0_6; -.
DR   OMA; FKIHTFS; -.
DR   OrthoDB; 1558246at2; -.
DR   Proteomes; UP000008148; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01577; MFS_MdtD; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023721; Multi-R_MdtD.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..471
FT                   /note="Putative multidrug resistance protein MdtD"
FT                   /id="PRO_0000365277"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        102..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        342..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
SQ   SEQUENCE   471 AA;  50934 MW;  BF470F816A10C232 CRC64;
     MTELPDSTRW QLWIVAFGFF MQSLDTTIVN TALPSMALSL GESPLHMHMV VVSYVLTVAV
     MLPASGWLAD KVGVRNIFFT AIVLFTLGSL FCAWSSTLNE LVLARVLQGV GGAMMVPVGR
     LTVMKIVPRE QYMAAMTFVT LPGQVGPLLG PALGGILVEY ASWHWIFLIN IPVGIVGAIA
     TLMLMPNYTM QTRRFDLSGF LLLAVGMAVL TMALDGSKGT GLSPLSLGAL VLCGILAIAL
     YLKHAKNNPR ALFSLALFRT HTFSLGLSGS FAGRVGSGML PFMTPVFLQI GLGFSPFHAG
     LMMIPMVLGS MGMKRIVVQV VNRFGYRRVL VATTLGLSLV SLLFMSVAML GWYYALPFVL
     FLQGMVNSTR FSSMNTLTLK DLPDELASSG NSLLSMIMQL SMSIGVTIAG LLLGMFGQQH
     IAADSGASHT VFMYTWLCMA LIIALPALIF ARVPNDTHKN AVISRRKRST Q