ID   MDTD_CROS8              Reviewed;         471 AA.
AC   A7MHI9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Putative multidrug resistance protein MdtD {ECO:0000255|HAMAP-Rule:MF_01577};
GN   Name=mdtD {ECO:0000255|HAMAP-Rule:MF_01577}; OrderedLocusNames=ESA_01141;
OS   Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Cronobacter.
OX   NCBI_TaxID=290339;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-894;
RX   PubMed=20221447; DOI=10.1371/journal.pone.0009556;
RA   Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L.,
RA   Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A.,
RA   Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K.,
RA   McClelland M., Forsythe S.J.;
RT   "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic
RT   hybridization analysis with other Cronobacter species.";
RL   PLoS ONE 5:E9556-E9556(2010).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01577}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01577}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000255|HAMAP-Rule:MF_01577}.
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DR   EMBL; CP000783; ABU76408.1; -; Genomic_DNA.
DR   RefSeq; WP_012124310.1; NC_009778.1.
DR   AlphaFoldDB; A7MHI9; -.
DR   SMR; A7MHI9; -.
DR   EnsemblBacteria; ABU76408; ABU76408; ESA_01141.
DR   KEGG; esa:ESA_01141; -.
DR   PATRIC; fig|290339.8.peg.1011; -.
DR   HOGENOM; CLU_000960_28_0_6; -.
DR   OMA; FKIHTFS; -.
DR   OrthoDB; 1558246at2; -.
DR   Proteomes; UP000000260; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01577; MFS_MdtD; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023721; Multi-R_MdtD.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..471
FT                   /note="Putative multidrug resistance protein MdtD"
FT                   /id="PRO_1000087927"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        263..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        290..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        342..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
SQ   SEQUENCE   471 AA;  50788 MW;  783B1778FB7E218B CRC64;
     MTDLPQNVRW QLWIVAFGFF MQALDTTIVN TALPSMAASL GESPLRMHMV IVSYVLTVAV
     MLPASGWLAD RVGVRNIFFT AIVLFTLGSL FCAQSSTLNE LVAARVLQGI GGAMMVPVGR
     LTVMKIVPRD QYMAAMTFVT LPGQVGPLLG PALGGLLVEY ASWHWIFLIN LPVGIAGAAA
     TLWLMPNYTM QTRRFDFSGF LLLAFGMAAL TIALDGYRST GLSPAGLGAL VAGGSAATLL
     YLWHARGNER ALFSLRLFNT RTFSLGLFGS LCGRIGSGML PFMTPVFLQI GLGFSPFHAG
     LMMMPMVLGS MGIKRIVVQV VNRFGYRRVL VASTLALALV TLLFMGVALA GWYWLLPVVM
     LFQGMVNSVR FSTMNTLTLR DLPDEMASSG NSLLSMVMQL SMSLGVSIAG LLLGAFGHNQ
     LAADSGDAHG IFFWTYLCMA LIIALPALVF ARVPDDISKN AVIARRKRSA S