MDTD_KLEP7
ID MDTD_KLEP7 Reviewed; 471 AA.
AC A6TBH6;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Putative multidrug resistance protein MdtD {ECO:0000255|HAMAP-Rule:MF_01577};
GN Name=mdtD {ECO:0000255|HAMAP-Rule:MF_01577};
GN OrderedLocusNames=KPN78578_24860; ORFNames=KPN_02529;
OS Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=272620;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700721 / MGH 78578;
RG The Klebsiella pneumonia Genome Sequencing Project;
RA McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01577}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01577}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC family. {ECO:0000255|HAMAP-Rule:MF_01577}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000647; ABR77947.1; -; Genomic_DNA.
DR RefSeq; WP_004149057.1; NC_009648.1.
DR AlphaFoldDB; A6TBH6; -.
DR SMR; A6TBH6; -.
DR STRING; 272620.KPN_02529; -.
DR EnsemblBacteria; ABR77947; ABR77947; KPN_02529.
DR KEGG; kpn:KPN_02529; -.
DR HOGENOM; CLU_000960_28_0_6; -.
DR OMA; FKIHTFS; -.
DR Proteomes; UP000000265; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1250.20; -; 1.
DR HAMAP; MF_01577; MFS_MdtD; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR023721; Multi-R_MdtD.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..471
FT /note="Putative multidrug resistance protein MdtD"
FT /id="PRO_1000069265"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 102..124
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 329..351
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
SQ SEQUENCE 471 AA; 50694 MW; E5B366C4B820A6C3 CRC64;
MTDLPASVRW QLWIVAFGFF MQSLDTTIVN TALPSMAKSL GESPLHMHMI IVSYVLTVAV
MLPASGWLAD RVGVRNIFFT AIVLFTAGSL FCAQASTLDQ LVMARVLQGV GGAMMVPVGR
LTVMKIVPRD QYMAAMTFVT LPGQVGPLLG PALGGVLVEY ASWHWIFLIN IPVGIVGAIA
TLCLMPNYTM QTRRFDLSGF LLLAAGMATL TLALDGQKGL GISPAWLAGL VAVGLCALLL
YLWHARGNAR ALFSLNLFRN RTFSLGLGGS FAGRIGSGML PFMTPVFLQI GLGFSPFHAG
LMMIPMVLGS MGMKRIVVQV VNRFGYRRVL VASTLGLAAV SLLFMFSALA GWYYVLPLVL
FLQGMINASR FSSMNTLTLK DLPDDLASSG NSLLSMVMQL SMSIGVTIAG LLLGLYGQQH
MSLDAASTHQ VFLYTYLSMA AIIALPALIF SRVPDDVGSN TVLRRRNRSG S