ID   MDTD_PECAS              Reviewed;         466 AA.
AC   Q6D2A9;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Putative multidrug resistance protein MdtD {ECO:0000255|HAMAP-Rule:MF_01577};
GN   Name=mdtD {ECO:0000255|HAMAP-Rule:MF_01577}; OrderedLocusNames=ECA3187;
OS   Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS   carotovora subsp. atroseptica).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=218491;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCRI 1043 / ATCC BAA-672;
RX   PubMed=15263089; DOI=10.1073/pnas.0402424101;
RA   Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J.,
RA   Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K.,
RA   Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J.,
RA   Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Norbertczak H.,
RA   Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S.,
RA   Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K.;
RT   "Genome sequence of the enterobacterial phytopathogen Erwinia carotovora
RT   subsp. atroseptica and characterization of virulence factors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01577}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01577}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000255|HAMAP-Rule:MF_01577}.
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DR   EMBL; BX950851; CAG76085.1; -; Genomic_DNA.
DR   RefSeq; WP_011094709.1; NC_004547.2.
DR   AlphaFoldDB; Q6D2A9; -.
DR   SMR; Q6D2A9; -.
DR   STRING; 218491.ECA3187; -.
DR   EnsemblBacteria; CAG76085; CAG76085; ECA3187.
DR   GeneID; 57209872; -.
DR   KEGG; eca:ECA3187; -.
DR   PATRIC; fig|218491.5.peg.3228; -.
DR   eggNOG; COG0477; Bacteria.
DR   HOGENOM; CLU_000960_28_0_6; -.
DR   OMA; FKIHTFS; -.
DR   OrthoDB; 1558246at2; -.
DR   Proteomes; UP000007966; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01577; MFS_MdtD; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023721; Multi-R_MdtD.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..466
FT                   /note="Putative multidrug resistance protein MdtD"
FT                   /id="PRO_0000268595"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        328..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        351..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        429..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
SQ   SEQUENCE   466 AA;  50720 MW;  6B9401888F386686 CRC64;
     MTQPASVRWQ LWIVAFGFFM QTLDTTIVNT ALPSMAASLN ESPLHMHSVI VSYVLTVAVM
     LPASGWLADR IGVKNIFFAA ILLFTLGSLL CARSETLDEL LISRVIQGIG GAMMVPVGRL
     TVMKIVPRDQ YMAAMTFVTL PGQIGPLLGP ALGGFLVEYA SWHWIFLINL PVGIIGALAT
     WFLMPNYTMQ TQRFDISGFV WLAVGMATLT LALDGNRSLG IPPIAIFALI AIGLIALLSY
     WLHARRNERA LFNLRLFDTH TFSIGLTGGL LARIGSGMLP FMTPLFLQLG MGFSPFHAGL
     MMVPMVLGSM GIKRVVVQIV NRFGYRRVLV ASTLLLALVT ALFALVALMQ WIWMIPVVLF
     FLGTVNAIRF STMNTLTLKD LPDPLASGGN SLLSMTMQLS TSLGVSIAGI LLGIFSQPHI
     AAESGATHTV FLYTYLSMVV IIALPALIFN RVPPDTLKQS TLARKS