ID   MDTD_SERP5              Reviewed;         477 AA.
AC   A8GHR1;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Putative multidrug resistance protein MdtD {ECO:0000255|HAMAP-Rule:MF_01577};
GN   Name=mdtD {ECO:0000255|HAMAP-Rule:MF_01577}; OrderedLocusNames=Spro_3555;
OS   Serratia proteamaculans (strain 568).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=399741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=568;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L.,
RA   Vangronsveld J., van der Lelie D., Richardson P.;
RT   "Complete sequence of chromosome of Serratia proteamaculans 568.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01577}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01577}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000255|HAMAP-Rule:MF_01577}.
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DR   EMBL; CP000826; ABV42651.1; -; Genomic_DNA.
DR   RefSeq; WP_012146264.1; NC_009832.1.
DR   AlphaFoldDB; A8GHR1; -.
DR   SMR; A8GHR1; -.
DR   STRING; 399741.Spro_3555; -.
DR   EnsemblBacteria; ABV42651; ABV42651; Spro_3555.
DR   KEGG; spe:Spro_3555; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_000960_28_0_6; -.
DR   OMA; FKIHTFS; -.
DR   OrthoDB; 1558246at2; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01577; MFS_MdtD; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023721; Multi-R_MdtD.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..477
FT                   /note="Putative multidrug resistance protein MdtD"
FT                   /id="PRO_0000365290"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        326..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        352..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        394..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT   TRANSMEM        432..452
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
SQ   SEQUENCE   477 AA;  51513 MW;  B7A2A08ED2CEE58C CRC64;
     MLIKHTASVQ WQLWIVAFGF FMQTLDTTIV NTALPSMAVS LGENPLRMQS VIVSYVLTVA
     VMLPASGWLA DRVGVQRVFF SAIVLFTLGS ILCARSETLN ELIASRVVQG IGGAMMVPVG
     RLTVMKIVPR EQYMAAMTFV TLPGQIGPLM GPALGGFLVQ YASWHWIFLI NIPVGIAGAI
     ATLLLMPNYR MQTRRFDISG FILLAVGMAT LTLALDGHKG MGLSATAIAG LVVAGVAALA
     GYWWHAHGNS RALFSLRLFK TRTYKVGLTA SLLGRIGSGM LPFMTPLFMQ VGMGFSPFHA
     GLMMIPMIIG SMGMKRIVVR VVNRFGYRNV LVAATLMLAL ISLSFPLVAM LGWIWLLPVV
     LFFQGMVNSL RFSAMNTLTL KDLPDRLASS GNSLLSMVMQ LSMSLGVSIA GILIGSFAHH
     QVVTDSPAIH SAFIYSYCCM ALIIALPALA FARVPADTTT NRTLTKEPGT GSTRLQQ