ID   MDTD_SHIDS              Reviewed;         348 AA.
AC   Q32EI1;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Putative multidrug resistance protein MdtD;
GN   Name=mdtD; OrderedLocusNames=SDY_2188;
OS   Shigella dysenteriae serotype 1 (strain Sd197).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=300267;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sd197;
RX   PubMed=16275786; DOI=10.1093/nar/gki954;
RA   Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J.,
RA   Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J.,
RA   Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J.,
RA   Jin Q.;
RT   "Genome dynamics and diversity of Shigella species, the etiologic agents of
RT   bacillary dysentery.";
RL   Nucleic Acids Res. 33:6445-6458(2005).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. This sequence is much
CC       shorter than orthologs. {ECO:0000305}.
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DR   EMBL; CP000034; ABB62274.1; -; Genomic_DNA.
DR   RefSeq; YP_403765.1; NC_007606.1.
DR   AlphaFoldDB; Q32EI1; -.
DR   SMR; Q32EI1; -.
DR   STRING; 300267.SDY_2188; -.
DR   EnsemblBacteria; ABB62274; ABB62274; SDY_2188.
DR   KEGG; sdy:SDY_2188; -.
DR   PATRIC; fig|300267.13.peg.2646; -.
DR   HOGENOM; CLU_796686_0_0_6; -.
DR   Proteomes; UP000002716; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   5: Uncertain;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..348
FT                   /note="Putative multidrug resistance protein MdtD"
FT                   /id="PRO_0000268600"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   348 AA;  38004 MW;  15A76F07F3494641 CRC64;
     MEYASWHWIF LINIPVGIIG AIATLMLMPN YTMQTRRFDL SGFLLLAVGM AVLTLALDGS
     KGTGLSPLAI AGLVAVGVVA LVLYLLHARN NNRALFSLKL FRTRTFSLGL AGGFAGRIGS
     GMLPFMTPVF LQIGLGFSPF HAGLMMIPMV LGSMGMKRIV VQVVNHFGYR RVLVATTLGL
     SLVTLLFMTT ALLGWYYVLP FVLFLQGMVN STRFSSMNTL TLKDLPDNLA SSGNSLLSMI
     MQLSMSIGVT IAGLLLGLFG SQHVSVDSGT TKPSLCTPGL AWRLSSPFRR SSLPECQTIR
     IKTWLFRVEK GARNEVLAAR YYRQTVSGDF RHLHCLADQY ALGGAYQF