MDTD_SHIF8
ID MDTD_SHIF8 Reviewed; 471 AA.
AC Q0T353;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 2.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Putative multidrug resistance protein MdtD {ECO:0000255|HAMAP-Rule:MF_01577};
GN Name=mdtD {ECO:0000255|HAMAP-Rule:MF_01577}; OrderedLocusNames=SFV_2138;
OS Shigella flexneri serotype 5b (strain 8401).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=373384;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=8401;
RX PubMed=16822325; DOI=10.1186/1471-2164-7-173;
RA Nie H., Yang F., Zhang X., Yang J., Chen L., Wang J., Xiong Z., Peng J.,
RA Sun L., Dong J., Xue Y., Xu X., Chen S., Yao Z., Shen Y., Jin Q.;
RT "Complete genome sequence of Shigella flexneri 5b and comparison with
RT Shigella flexneri 2a.";
RL BMC Genomics 7:173-173(2006).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01577}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01577}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC family. {ECO:0000255|HAMAP-Rule:MF_01577}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABF04262.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; CP000266; ABF04262.1; ALT_FRAME; Genomic_DNA.
DR AlphaFoldDB; Q0T353; -.
DR SMR; Q0T353; -.
DR EnsemblBacteria; ABF04262; ABF04262; SFV_2138.
DR KEGG; sfv:SFV_2138; -.
DR HOGENOM; CLU_000960_28_0_6; -.
DR Proteomes; UP000000659; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1250.20; -; 1.
DR HAMAP; MF_01577; MFS_MdtD; 1.
DR InterPro; IPR004638; EmrB-like.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR023721; Multi-R_MdtD.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..471
FT /note="Putative multidrug resistance protein MdtD"
FT /id="PRO_0000280492"
FT TOPO_DOM 1..12
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TOPO_DOM 34..48
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TOPO_DOM 70..76
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TOPO_DOM 98..101
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 102..124
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TOPO_DOM 125..137
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TOPO_DOM 159..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TOPO_DOM 186..196
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TOPO_DOM 218..224
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TOPO_DOM 246..262
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TOPO_DOM 284..285
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TOPO_DOM 307..341
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TOPO_DOM 363..395
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TOPO_DOM 417..430
FT /note="Periplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
FT TOPO_DOM 452..471
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01577"
SQ SEQUENCE 471 AA; 50923 MW; 0CBEE504D3A4A145 CRC64;
MTDLPDSTRW QLWIVAFGFF MQSLDTTIVN TAIPSMAQSL GESPLHMHMV IVSYVLTVAV
MLPASGWLAD KVGVRNIFFT AIVLFTLGSL FCALSGTLNE LLLARALQGV GGAMMVPVGR
LTVMKIVPRE QYMAAMTFVT LPGQVGPLLG PALGGLLVEY ASWHWIFLIN IPVGIIGAIA
TLMLMPNYTM QTRRFDLSGF LLLAVGMAVL TLALDGSKGT GLSPLAIAGL VAVGVVALVL
YLLHARNNNR ALFSLKLFRT RTFSLGLAGS FAGRIGSGML PFMTPVFLQI GLGFSPFHAG
LMMIPMVLGS MGMKRIVVQV VNRFGYRRVL VATTLGLSLV TLLFMTTALL GWYYVLPFVL
FLQGMVNSTR FSSMNTLTLK DLPDNLASSG NSLLSMIMQL SMSIGVTIAG LLLGLFGSQH
VSVDSGTTQT VFMYTWLSMA FIIALPAFIF ARVPNDTHQN VAISRRKRSA Q