ID   MDTG_ESCF3              Reviewed;         408 AA.
AC   B7LT82;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Multidrug resistance protein MdtG {ECO:0000255|HAMAP-Rule:MF_01528};
GN   Name=mdtG {ECO:0000255|HAMAP-Rule:MF_01528}; OrderedLocusNames=EFER_1875;
OS   Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM
OS   14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585054;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35469 / DSM 13698 / BCRC 15582 / CCUG 18766 / IAM 14443 / JCM
RC   21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73;
RX   PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA   Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA   Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA   Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA   Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA   Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA   Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA   Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT   "Organised genome dynamics in the Escherichia coli species results in
RT   highly diverse adaptive paths.";
RL   PLoS Genet. 5:E1000344-E1000344(2009).
CC   -!- FUNCTION: Confers resistance to fosfomycin and deoxycholate.
CC       {ECO:0000255|HAMAP-Rule:MF_01528}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01528}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01528}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC       MdtG (TC 2.A.1.2.20) subfamily. {ECO:0000255|HAMAP-Rule:MF_01528}.
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DR   EMBL; CU928158; CAQ89386.1; -; Genomic_DNA.
DR   RefSeq; WP_000075067.1; NC_011740.1.
DR   AlphaFoldDB; B7LT82; -.
DR   SMR; B7LT82; -.
DR   EnsemblBacteria; CAQ89386; CAQ89386; EFER_1875.
DR   KEGG; efe:EFER_1875; -.
DR   HOGENOM; CLU_001265_57_3_6; -.
DR   OMA; VIRHNVP; -.
DR   OrthoDB; 626204at2; -.
DR   BioCyc; EFER585054:EFER_RS09415-MON; -.
DR   Proteomes; UP000000745; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   HAMAP; MF_01528; MFS_MdtG; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023692; Mutidrug-R_MdtG.
DR   InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR   Pfam; PF07690; MFS_1; 1.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   PRINTS; PR01035; TCRTETA.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell inner membrane; Cell membrane; Membrane;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..408
FT                   /note="Multidrug resistance protein MdtG"
FT                   /id="PRO_1000200786"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        319..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
SQ   SEQUENCE   408 AA;  43911 MW;  95EC8030A36D90AC CRC64;
     MSPSESDDAI NWKRNLIVAW LGCFLTGAAF SLVMPFLPLY VEELGVTGHS ALNLWSGIVF
     SITFLFSAIA SPFWGGLADR KGRKIMLLRS ALGMGIVMIL MGMAQNIWQF LILRALLGLL
     GGFVPNANAL IATQVPRNKS GWALGTLSTG GVSGALLGPL AGGLLADHYG LRPVFFITAS
     VLMLCFVVTL LCIKEKFQPV SKKEMLHVRE VVFSLKNPRL VLSLFVTTMI IQIASGSIAP
     ILTLYVRELA GNVGNIAFIS GMIASVPGVA ALLSAPRLGK LGDRIGPDKI LIAALIFSVL
     LLIPMSFVQT PWQLGILRFL LGAADGALLP AVQTLLVYNS SNQIAGRIFS YNQSFRDIGN
     VTGPLMGAAI SANYGFRAVF LVTACVVLFN IIYSWNSLRR RREPQVLG