ID   MDTG_KLEP3              Reviewed;         412 AA.
AC   B5XXK2;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Multidrug resistance protein MdtG {ECO:0000255|HAMAP-Rule:MF_01528};
GN   Name=mdtG {ECO:0000255|HAMAP-Rule:MF_01528}; OrderedLocusNames=KPK_3490;
OS   Klebsiella pneumoniae (strain 342).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=507522;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=342;
RX   PubMed=18654632; DOI=10.1371/journal.pgen.1000141;
RA   Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H.,
RA   Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y.,
RA   Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W.,
RA   Methe B.A.;
RT   "Complete genome sequence of the N2-fixing broad host range endophyte
RT   Klebsiella pneumoniae 342 and virulence predictions verified in mice.";
RL   PLoS Genet. 4:E1000141-E1000141(2008).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01528}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01528}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC       MdtG (TC 2.A.1.2.20) subfamily. {ECO:0000255|HAMAP-Rule:MF_01528}.
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DR   EMBL; CP000964; ACI11362.1; -; Genomic_DNA.
DR   AlphaFoldDB; B5XXK2; -.
DR   SMR; B5XXK2; -.
DR   EnsemblBacteria; ACI11362; ACI11362; KPK_3490.
DR   KEGG; kpe:KPK_3490; -.
DR   HOGENOM; CLU_001265_57_3_6; -.
DR   OMA; VIRHNVP; -.
DR   OrthoDB; 626204at2; -.
DR   Proteomes; UP000001734; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   HAMAP; MF_01528; MFS_MdtG; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023692; Mutidrug-R_MdtG.
DR   InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR   Pfam; PF07690; MFS_1; 1.
DR   PRINTS; PR01035; TCRTETA.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..412
FT                   /note="Multidrug resistance protein MdtG"
FT                   /id="PRO_0000414580"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
SQ   SEQUENCE   412 AA;  44153 MW;  9085BC75E2FF89A7 CRC64;
     MSSADTPINW KQNLTVTWLG CFLTGAAFSL VMPFLPLYVE QLGVTGHSAL NMWSGLVFSI
     TFLFSAIASP FWGGLADRKG RKIMLLRSAL GMSVVMMLMG MAQNIWQFLL LRALLGLLGG
     FIPNANALIA TQIPRHKSGW ALGTLSTGAV SGALLGPLAG GFLADHWGLR TVFFMTAAVL
     FICFLFTLFL IRENFVPIAK KEMLSAREVF SSLQNPKLVL SLFVTSLIIQ VATGSIAPIL
     TLYVRDLAGN VSNIAFISGM IASVPGIAAL MSAPRLGRLG DRIGPEKILI VALIISVLLL
     IPMSFVQTPL QLGILRFLLG AADGALLPAV QTLLVYNSTS QISGRIFSYN QSFRDIGNVT
     GPLIGASVSA NYGFRAVFLV TAGVVLFNAI YSTLSLRRPA AEASQPDRHS VN