ID   MDTG_SERP5              Reviewed;         411 AA.
AC   A8GCZ5;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Multidrug resistance protein MdtG {ECO:0000255|HAMAP-Rule:MF_01528};
GN   Name=mdtG {ECO:0000255|HAMAP-Rule:MF_01528}; OrderedLocusNames=Spro_1882;
OS   Serratia proteamaculans (strain 568).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=399741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=568;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L.,
RA   Vangronsveld J., van der Lelie D., Richardson P.;
RT   "Complete sequence of chromosome of Serratia proteamaculans 568.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01528}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01528}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC       MdtG (TC 2.A.1.2.20) subfamily. {ECO:0000255|HAMAP-Rule:MF_01528}.
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DR   EMBL; CP000826; ABV40985.1; -; Genomic_DNA.
DR   RefSeq; WP_012006307.1; NC_009832.1.
DR   AlphaFoldDB; A8GCZ5; -.
DR   SMR; A8GCZ5; -.
DR   STRING; 399741.Spro_1882; -.
DR   EnsemblBacteria; ABV40985; ABV40985; Spro_1882.
DR   KEGG; spe:Spro_1882; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_001265_57_3_6; -.
DR   OMA; VIRHNVP; -.
DR   OrthoDB; 626204at2; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   HAMAP; MF_01528; MFS_MdtG; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023692; Mutidrug-R_MdtG.
DR   InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG.
DR   Pfam; PF07690; MFS_1; 1.
DR   Pfam; PF00083; Sugar_tr; 1.
DR   PRINTS; PR01035; TCRTETA.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..411
FT                   /note="Multidrug resistance protein MdtG"
FT                   /id="PRO_0000414583"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01528"
SQ   SEQUENCE   411 AA;  44611 MW;  2E020594C5D1C7B4 CRC64;
     MAPAPKLINW KRNLFVAWLG CFLTGAAFSL IMPFLPLYVE TLGVTGHQAL NMWSGLVFSI
     TFLFSAIASP FWGGLADRRG RKLMLLRSAL GMSIVMLLMG MAQNIWQFLA LRAVLGLLGG
     FIPNANALIA TQVPRNRSGW ALGTLSTGGV SGALIGPLIG GLLADQYGLR PVFYITAGVL
     LTCFVLTLLY VKEQFTPVQK KDMLHARQVF AALKSPKLIL SLFVTTMIIQ IATGSIAPIL
     TLYVRDLAGD IHNLAFVSGL IASVPGVAAL MSAPRLGKLG DRIGPERILV FMLIVSVLLL
     IPMAFVQTPW QLGVLRFLLG AADGALLPAV QTLLIYNCTN QVAGRIFSYN QSFRDIGNVS
     GPLMGAAVSA SYGFRAVFCV TALVVLFNAV YSWWCLQRRP TRMREDTLQE E