MDTH_AERS4
ID MDTH_AERS4 Reviewed; 397 AA.
AC A4SR87;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Multidrug resistance protein MdtH {ECO:0000255|HAMAP-Rule:MF_01529};
GN Name=mdtH {ECO:0000255|HAMAP-Rule:MF_01529}; OrderedLocusNames=ASA_3438;
OS Aeromonas salmonicida (strain A449).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC Aeromonadaceae; Aeromonas.
OX NCBI_TaxID=382245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A449;
RX PubMed=18801193; DOI=10.1186/1471-2164-9-427;
RA Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J.,
RA Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C.,
RA Brown L.L.;
RT "The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into
RT the evolution of a fish pathogen.";
RL BMC Genomics 9:427-427(2008).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01529}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01529}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC MdtH (TC 2.A.1.2.21) subfamily. {ECO:0000255|HAMAP-Rule:MF_01529}.
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DR EMBL; CP000644; ABO91409.1; -; Genomic_DNA.
DR RefSeq; WP_011899059.1; NC_009348.1.
DR AlphaFoldDB; A4SR87; -.
DR SMR; A4SR87; -.
DR STRING; 382245.ASA_3438; -.
DR EnsemblBacteria; ABO91409; ABO91409; ASA_3438.
DR KEGG; asa:ASA_3438; -.
DR PATRIC; fig|382245.13.peg.3423; -.
DR eggNOG; COG0477; Bacteria.
DR HOGENOM; CLU_001265_60_2_6; -.
DR OMA; TVCVWTL; -.
DR OrthoDB; 1452500at2; -.
DR Proteomes; UP000000225; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1250.20; -; 1.
DR HAMAP; MF_01529; MFS_MdtH; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR022855; Multidrug-R_MdtH.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..397
FT /note="Multidrug resistance protein MdtH"
FT /id="PRO_1000185163"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 366..386
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
SQ SEQUENCE 397 AA; 42748 MW; CC9B6CFE645DBD91 CRC64;
MVERARRLGR WFLALDSLLV ILGFFVVMPM ISLRFVDQQG WAAGIVGLAL GLRQLTQQGL
GVLGGSLADK FGARPLIVGG MLLRAAGFAS LAYAQSGLEL ILSCIISGLG GCLFDPPRAA
LVIKFTRPRQ RGRYISLLMM LESAGAVVGA LLGSWLLNFD FEYVCLLGAG LFVCAALCNL
LILPPYKLSQ RPTPIRAGLG QVLADKAFCR LVLILSGYYA LWVQVMLIFP ILVKQMAGTT
TAVGWMYTLE TAISLTLLYP LARYGEKHFK LENRLMAGVL LMTTGIGLVA FATTLPAVFV
LLACFYLGIV IAEPARETLM TKLAQPGARG SYMGFSRLGL ALGGMTGYVG GGALHDYANA
QGQPWLPWLV LGTVGVTTLL LLVNCFHREP SLARVNI
