ID   MDTH_BAUCH              Reviewed;         411 AA.
AC   Q1LTM2;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 2.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Multidrug resistance protein MdtH {ECO:0000255|HAMAP-Rule:MF_01529};
GN   Name=mdtH {ECO:0000255|HAMAP-Rule:MF_01529}; OrderedLocusNames=BCI_0239;
OS   Baumannia cicadellinicola subsp. Homalodisca coagulata.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Candidatus Baumannia.
OX   NCBI_TaxID=374463;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16729848; DOI=10.1371/journal.pbio.0040188;
RA   Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H.,
RA   Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A.;
RT   "Metabolic complementarity and genomics of the dual bacterial symbiosis of
RT   sharpshooters.";
RL   PLoS Biol. 4:1079-1092(2006).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01529};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01529}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC       MdtH (TC 2.A.1.2.21) subfamily. {ECO:0000255|HAMAP-Rule:MF_01529}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABF13793.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000238; ABF13793.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_011520425.1; NC_007984.1.
DR   STRING; 374463.BCI_0239; -.
DR   EnsemblBacteria; ABF13793; ABF13793; BCI_0239.
DR   KEGG; bci:BCI_0239; -.
DR   HOGENOM; CLU_001265_60_2_6; -.
DR   OrthoDB; 1452500at2; -.
DR   Proteomes; UP000002427; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01529; MFS_MdtH; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR022855; Multidrug-R_MdtH.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..411
FT                   /note="Multidrug resistance protein MdtH"
FT                   /id="PRO_0000280494"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        73..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        99..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
SQ   SEQUENCE   411 AA;  45858 MW;  F626BEB937B8C1DD CRC64;
     MSSVSQARSL GKYFLLMDNI LVVMGFYMVF PLISIRFVDQ LGWTALLVGI ALGLRQFIQQ
     GLGIFGGAFA DKLGAKPMII TGMLMRALGF IFMGIADKPW LLWVSCILSA LGGTLFDPPR
     TALVMKLTRP WERGRFYSLL MIQDSTCAMV GALLGSWLLQ YNFKLVCLAG ALLFLFAAIL
     NAWLLPAYRI SNAQTSMLEG IRRVLYDQRF VTYVFTLTGY YILSVQVMLI LPIRVNEVAG
     QLAAVRWTYA IEAALSLSLL YPIARWSEKR FSLENRFMAG LTIMLLSIIP IGMIHNLQVL
     FLLIGIFYTG SIIAEPARET LGASLADNRA RGSYMGFSRL GLALGGAIGY SGGGWLYDMG
     NQLDIPQLPW VMLGMIGLIT LLGFYRQFHQ HHYQTYSXYL SGTTKNNSYK Q