MDTH_EDWI9
ID MDTH_EDWI9 Reviewed; 402 AA.
AC C5B828;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Multidrug resistance protein MdtH {ECO:0000255|HAMAP-Rule:MF_01529};
GN Name=mdtH {ECO:0000255|HAMAP-Rule:MF_01529}; OrderedLocusNames=NT01EI_1580;
OS Edwardsiella ictaluri (strain 93-146).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Hafniaceae; Edwardsiella.
OX NCBI_TaxID=634503;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=93-146;
RA Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01529}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01529}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC MdtH (TC 2.A.1.2.21) subfamily. {ECO:0000255|HAMAP-Rule:MF_01529}.
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DR EMBL; CP001600; ACR68764.1; -; Genomic_DNA.
DR RefSeq; WP_015870922.1; NC_012779.2.
DR AlphaFoldDB; C5B828; -.
DR SMR; C5B828; -.
DR STRING; 67780.B6E78_01090; -.
DR EnsemblBacteria; ACR68764; ACR68764; NT01EI_1580.
DR GeneID; 7961908; -.
DR KEGG; eic:NT01EI_1580; -.
DR PATRIC; fig|634503.3.peg.1412; -.
DR HOGENOM; CLU_001265_60_2_6; -.
DR OMA; TVCVWTL; -.
DR OrthoDB; 1452500at2; -.
DR Proteomes; UP000001485; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1250.20; -; 1.
DR HAMAP; MF_01529; MFS_MdtH; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR022855; Multidrug-R_MdtH.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..402
FT /note="Multidrug resistance protein MdtH"
FT /id="PRO_1000215397"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 99..116
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
SQ SEQUENCE 402 AA; 44143 MW; 797A44ABE0A3B90F CRC64;
MSLVLQARRS GKYFLLIDNL LVVLGFFVVF PLISIRFVDQ LGWAALIVGI ALGLRQLLQQ
GLGIFGGAIA DRVGAKPMII SGMLLRAAGF ATMAVASEPW ILWASCTLSA LGGTLFDPPR
TALVIKLTRP HERGRFYSLL MMQDSAGAVI GALIGSWLLA YDFHYVCWAG AALFVLAAAW
NAWLLPAYRI STIRAPVREG MLRVVRDRRF LTYVLTLTGY YMLAVQVMLM LPIMVNDIAG
GPGAVKWMYA IEAALSLTLL YPIARWSEKR FRLEQRLMFG LLLMTLSLFP LGLSTTLQSL
FALICCFYLG SIIAEPARET LSASLADARA RGSYMGFSRL GLALGGALGY TGGGWMYDMG
RSMNMPELPW ALLGIIGMLT LALLYWQFSL QVPCATHQPR SS
