ID   MDTH_PECAS              Reviewed;         401 AA.
AC   Q6D469;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Multidrug resistance protein MdtH {ECO:0000255|HAMAP-Rule:MF_01529};
GN   Name=mdtH {ECO:0000255|HAMAP-Rule:MF_01529}; OrderedLocusNames=ECA2525;
OS   Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS   carotovora subsp. atroseptica).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=218491;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCRI 1043 / ATCC BAA-672;
RX   PubMed=15263089; DOI=10.1073/pnas.0402424101;
RA   Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J.,
RA   Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K.,
RA   Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J.,
RA   Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Norbertczak H.,
RA   Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S.,
RA   Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K.;
RT   "Genome sequence of the enterobacterial phytopathogen Erwinia carotovora
RT   subsp. atroseptica and characterization of virulence factors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01529}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01529}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC       MdtH (TC 2.A.1.2.21) subfamily. {ECO:0000255|HAMAP-Rule:MF_01529}.
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DR   EMBL; BX950851; CAG75424.1; -; Genomic_DNA.
DR   RefSeq; WP_011094070.1; NC_004547.2.
DR   AlphaFoldDB; Q6D469; -.
DR   SMR; Q6D469; -.
DR   STRING; 218491.ECA2525; -.
DR   EnsemblBacteria; CAG75424; CAG75424; ECA2525.
DR   GeneID; 57208779; -.
DR   KEGG; eca:ECA2525; -.
DR   PATRIC; fig|218491.5.peg.2555; -.
DR   eggNOG; COG0477; Bacteria.
DR   HOGENOM; CLU_001265_60_2_6; -.
DR   OMA; TVCVWTL; -.
DR   OrthoDB; 1452500at2; -.
DR   Proteomes; UP000007966; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_01529; MFS_MdtH; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR022855; Multidrug-R_MdtH.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..401
FT                   /note="Multidrug resistance protein MdtH"
FT                   /id="PRO_0000173345"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        99..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        300..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01529"
SQ   SEQUENCE   401 AA;  44507 MW;  AB61B33D81587254 CRC64;
     MPLMSQARSL GKYFLLLDNM LVVLGFFVVF PLISIRFVDQ LGWAALLVGI ALGLRQFIQQ
     GLGIFGGAIA DRFGAKPMII TGMLLRASGF VFMAIADEPW LLWLSCALSG LGGTLFDPPR
     TALVIKLIRP QERGRFYSLL MMQDSAGAVI GALLGSWLLQ YDFEVVCWVG AVIFVLVAGL
     NAWLLPAYRI STVRTPIKEG LMRVIRDRRF LMYVLTLTGY YMLAVQVLLM LPIMVNEIAG
     TPSAVKWMYA IEAVLSLTLL YPIARWSEKR FRLEQRLMVG LFIMSVSMFP IGMTTELRPL
     LMLISLFYMG SIIAEPARET LSASLADSRA RGSYMGFSRL GLALGGAIGY SGGGWLFDTG
     HALNQPELPW FMLGTIGFLT LAALYWQFNQ RRIEPAMLGG H